IKs blockade in border zone arrhythmias from guinea-pig ventricular myocardium submitted to simulated ischemia and reperfusion

I Ks blockade might be a promising way to treat tachyarrhythmia because of the accumulation of activated potassium channels. However, IKs blockade during ischemia/reperfusion has not been investigated. Thus, the electrophysiological effects of two IKs blockers, chromanol 293B (10 μm) and HMR 1556 (1...

Full description

Saved in:
Bibliographic Details
Published in:Fundamental & clinical pharmacology 2012-08, Vol.26 (4), p.445-453
Main Authors: Puddu, Paolo Emilio, Sallé, Laurent, Gérard, Jean-Louis, Rouet, René, Ducroq, Joffrey
Format: Article
Language:English
Subjects:
arrhythmias
Biological and medical sciences
border zone
Cardiac dysrhythmias
Cardiology. Vascular system
chromanol 293B
guinea-pig
Heart
HMR 1556
IKs
ischemia and reperfusion
Medical sciences
Pharmacology. Drug treatments
ventricular myocardium
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:I Ks blockade might be a promising way to treat tachyarrhythmia because of the accumulation of activated potassium channels. However, IKs blockade during ischemia/reperfusion has not been investigated. Thus, the electrophysiological effects of two IKs blockers, chromanol 293B (10 μm) and HMR 1556 (1 μm), were assessed in an in vitro model of border zone between normal and ischemic/reperfused right ventricular myocardium from guinea‐pigs, and classic electrophysiological parameters and the incidence of arrhythmias were studied. HMR 1556 and chromanol 293B exhibited slight conventional class III effects on action potential duration in the normal zone (NZ) (APD90: −2 ± 5%, not significant (NS); +6 ± 3%, NS; and +5 ± 1%, P 
ISSN:0767-3981
1472-8206
DOI:10.1111/j.1472-8206.2011.00970.x