Antibacterial Activities of Grepafloxacin, Ciprofloxacin, Ofloxacin and Fleroxacin

Grepafloxacin (OPC-17116) and three other fluoroquinolones were tested against 461 bacterial isolates representing 44 species. Grepafloxacin was superior to ciprofloxacin, ofloxacin and fleroxacin in its activity against the Gram-positive cocci, including staphylococci, pneumo-cocci and hemolytic st...

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Bibliographic Details
Published in:Journal of chemotherapy (Florence) 1997-02, Vol.9 (1), p.9-16
Main Authors: Barry, A.L., Fuchs, P.C.
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria, Anaerobic - drug effects
Biological and medical sciences
Ciprofloxacin - pharmacology
Drug Evaluation, Preclinical
Drug Resistance, Microbial
Enterobacteriaceae - drug effects
Fleroxacin - pharmacology
Fluoroquinolones
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Medical sciences
Microbial Sensitivity Tests
Mutation
Ofloxacin - pharmacology
Pharmacology. Drug treatments
Piperazines - pharmacology
Quinolones - pharmacology
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Summary:Grepafloxacin (OPC-17116) and three other fluoroquinolones were tested against 461 bacterial isolates representing 44 species. Grepafloxacin was superior to ciprofloxacin, ofloxacin and fleroxacin in its activity against the Gram-positive cocci, including staphylococci, pneumo-cocci and hemolytic streptococci. Attempts to select grepafloxacin-resistant mutants from a methicillin-resistant Staphylococcus aureus strain were unsuccessful, although ciprofloxacin readily selected quinolone-resistant mutants of that strain. Among Gram-negative bacilli other than Escherichia coli, mutants were readily selected by in vitro exposure to either grepafloxacin or ciprofloxacin. All such mutants showed complete cross resistance to six other quinolones. The four study drugs were active against nalidixic acid-susceptible strains belonging to 13 species of the Enterobacteriaceae, but ciprofloxacin was the most potent drug studied. Against Acinetobacter spp. and Stenotrophomonas maltophilia, grepafloxacin was two- to four-times more active than ciprofloxacin. However, against Pseudomonas aeruginosa, ciprofloxacin was two- to four-times more potent than grepafloxacin. Grepafloxacin and ciprofloxacin were both found to be bactericidal agents.
ISSN:1120-009X
1973-9478
DOI:10.1179/joc.1997.9.1.9