Hollow poly(MPC-g-PEG-b-PLA) graft copolymer microcapsule as a potential drug carrier

In this article, an amphiphilic graft copolymer composed of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) as the hydrophilic backbone, poly(L-lactic acid) (PLA) as the hydrophobic side-chains and polyethylene glycol (PEG) as the spacer was synthesized. Transmission electron microscopy reveal...

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Bibliographic Details
Published in:Journal of microencapsulation 2012-05, Vol.29 (3), p.242-249
Main Authors: Liu, Chaoyong, Long, Lixia, Li, Zhi, He, Bin, Wang, Liuheng, Wang, Jiapeng, Yuan, Xubo, Sheng, Jing
Format: Article
Language:English
Subjects:
2-methacryloyloxyethyl phosphorylcholine
Adsorption
amphiphilic graft copolymer
Animals
antiadhesive
Antineoplastic Agents - administration & dosage
Biocompatible Materials - chemistry
Biological and medical sciences
Biomimetics
Capsules - chemistry
Cattle
controlled release
Drug Carriers - chemistry
Drug Delivery Systems
Electron Probe Microanalysis - methods
General pharmacology
hollow microcapsules
Humans
Lactic Acid - chemistry
Medical sciences
Methacrylates
Paclitaxel - administration & dosage
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phosphorylcholine - analogs & derivatives
Phosphorylcholine - chemistry
Polyesters
Polyethylene Glycols - chemistry
Polymers - chemistry
Polymethacrylic Acids
Serum Albumin, Bovine - chemistry
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Summary:In this article, an amphiphilic graft copolymer composed of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) as the hydrophilic backbone, poly(L-lactic acid) (PLA) as the hydrophobic side-chains and polyethylene glycol (PEG) as the spacer was synthesized. Transmission electron microscopy revealed that the graft copolymer could self-assemble into hollow microcapsules when dialyzed in aqueous solution and particle sizes ranged from 200 to 300 nm, while the graft copolymer formed core-shell microspheres with the absence of PEG spacer. X-ray photoelectron microscope showed that MPC polymers were located at the surface of the microcapsules. The amounts of adsorbed bovine serum albumin and Fg on the microcapsules were significantly decreased than that on the conventional PLA particles (74% and 60%, respectively), well indicating the anti-adhesive property of the microcapsules. Paclitaxel was chosen as a prototype anticancer drug for the encapsulation and release studies, the results showed that the drug encapsulation efficiency was 89.3 ± 1.2% and the microcapsules exhibited controlled release behaviour.
ISSN:0265-2048
1464-5246
DOI:10.3109/02652048.2011.646328