Hollow poly(MPC-g-PEG-b-PLA) graft copolymer microcapsule as a potential drug carrier

• Published in: Journal of microencapsulation 2012-05, Vol.29 (3), p.242-249
• Main Authors: Liu, Chaoyong, Long, Lixia, Li, Zhi, He, Bin, Wang, Liuheng, Wang, Jiapeng, Yuan, Xubo, Sheng, Jing
• Format: Article
• Language: English
• Subjects: 2-methacryloyloxyethyl phosphorylcholine; Adsorption; amphiphilic graft copolymer; Animals; antiadhesive; Antineoplastic Agents - administration & dosage; Biocompatible Materials - chemistry; Biological and medical sciences; Biomimetics; Capsules - chemistry; Cattle; controlled release; Drug Carriers - chemistry; Drug Delivery Systems; Electron Probe Microanalysis - methods; General pharmacology; hollow microcapsules; Humans; Lactic Acid - chemistry; Medical sciences; Methacrylates; Paclitaxel - administration & dosage; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Phosphorylcholine - analogs & derivatives; Phosphorylcholine - chemistry; Polyesters; Polyethylene Glycols - chemistry; Polymers - chemistry; Polymethacrylic Acids; Serum Albumin, Bovine - chemistry
• ISSN: 0265-2048; 1464-5246
• DOI: 10.3109/02652048.2011.646328

In this article, an amphiphilic graft copolymer composed of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) as the hydrophilic backbone, poly(L-lactic acid) (PLA) as the hydrophobic side-chains and polyethylene glycol (PEG) as the spacer was synthesized. Transmission electron microscopy revealed that the graft copolymer could self-assemble into hollow microcapsules when dialyzed in aqueous solution and particle sizes ranged from 200 to 300 nm, while the graft copolymer formed core-shell microspheres with the absence of PEG spacer. X-ray photoelectron microscope showed that MPC polymers were located at the surface of the microcapsules. The amounts of adsorbed bovine serum albumin and Fg on the microcapsules were significantly decreased than that on the conventional PLA particles (74% and 60%, respectively), well indicating the anti-adhesive property of the microcapsules. Paclitaxel was chosen as a prototype anticancer drug for the encapsulation and release studies, the results showed that the drug encapsulation efficiency was 89.3 ± 1.2% and the microcapsules exhibited controlled release behaviour.