SOLID-PHASE SYNTHESIS OF POLYMER-BOUND β-KETOESTERS AND THEIR APPLICATION IN THE SYNTHESIS OF STRUCTURALLY DIVERSE PYRAZOLONES

An efficient solid-phase synthesis of different polymer-bound β-ketoesters 7 is described using readily available acid chlorides 1 and haloalkanes 6 as building blocks. The corresponding pyrazolones 9 and 10 were obtained by mild acid catalyzed reaction with phenylhydrazine or by treatment with hydr...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1997-05, Vol.7 (10), p.1303-1306
Main Authors: Tietze, Lutz F, Steinmetz, Adrian, Balkenhohl, Friedhelm
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Organic chemistry
Preparations and properties
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Summary:An efficient solid-phase synthesis of different polymer-bound β-ketoesters 7 is described using readily available acid chlorides 1 and haloalkanes 6 as building blocks. The corresponding pyrazolones 9 and 10 were obtained by mild acid catalyzed reaction with phenylhydrazine or by treatment with hydrazine under cyclisation and cleavage from the resin in high purity and good yield. © 1997 Elsevier Science Ltd.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00209-6