Use of Solid Phase Microextraction (SPME) with Ion Mobility Spectrometry

We report the use of solid phase microextraction (SPME) combined with ion mobility spectrometry (IMS) for sampling, screening and identification of organic compounds that are readily detected by IMS. This is a new SPME application. SPME has emerged recently as an excellent sample preparation techniq...

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Bibliographic Details
Published in:Analytical letters 1997-05, Vol.30 (7), p.1437-1444
Main Authors: Orzechowska, Grazyna E., Poziomek, Edward J., Tersol, Vangielynn
Format: Article
Language:English
Subjects:
Analytical chemistry
Biological and medical sciences
Chemistry
cocaine
cocaine freebase
cocaine hydrochloride
Exact sciences and technology
field screening
General aspects. Methods
IMS
ion mobility spectrometry
Medical sciences
sample handling
sampling
solid phase microextraction
Spectrometric and optical methods
SPME
Toxicology
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Summary:We report the use of solid phase microextraction (SPME) combined with ion mobility spectrometry (IMS) for sampling, screening and identification of organic compounds that are readily detected by IMS. This is a new SPME application. SPME has emerged recently as an excellent sample preparation technique for gas chromatography (GC) and high performance liquid chromatography (HPLC). We have found that SPME can be used very conveniently with IMS. An example of SPME-IMS is described using SPME headspace sampling at room temperature with 0.1 mL vials containing 1.0 microgram or less of either cocaine freebase or cocaine hydrochloride. This is followed by analysis using IMS. A hole, drilled in the IMS sample ticket holder, serves as the SPME-IMS interface. *Presented in part at the SPIE (The International Society for Optical Engineering) Conference 2937, Chemistry- and Biology-Based Technologies for Contraband Detection, Boston, MA, November 1996.
ISSN:0003-2719
1532-236X
DOI:10.1080/00032719708007229