Physicochemical characterization and in vivo evaluation of solid self-nanoemulsifying drug delivery system for oral administration of docetaxel

To formulate a self-nanoemulsifying drug delivery system (SNEDDS) for the oral administration of docetaxel as an alternative to commercial docetaxel-loaded injectable products, it was prepared by spray-drying an aqueous solution containing liquid SNEDDS and colloidal silica. Its physicochemical prop...

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Bibliographic Details
Published in:Journal of microencapsulation 2013-01, Vol.30 (4), p.307-314
Main Authors: Quan, Qizhe, Kim, Dong-Wuk, Marasini, Nirmal, Kim, Dae Hwan, Kim, Jin Ki, Kim, Jong Oh, Yong, Chul Soon, Choi, Han-Gon
Format: Article
Language:English
Subjects:
absolute bioavailability
Administration, Oral
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - pharmacology
Biological and medical sciences
Biological Availability
capryol 90
cremophore EL
docetaxel
Drug Delivery Systems
Emulsions
General pharmacology
Male
Medical sciences
Nanoparticles - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Rats, Sprague-Dawley
Silicon Dioxide - chemistry
Silicon Dioxide - pharmacokinetics
Silicon Dioxide - pharmacology
solid self-nanoemulsifying drug delivery system
Taxoids - chemistry
Taxoids - pharmacokinetics
Taxoids - pharmacology
transcutol HP
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Summary:To formulate a self-nanoemulsifying drug delivery system (SNEDDS) for the oral administration of docetaxel as an alternative to commercial docetaxel-loaded injectable products, it was prepared by spray-drying an aqueous solution containing liquid SNEDDS and colloidal silica. Its physicochemical properties and oral bioavailability were investigated compared to a clear docetaxel solution administered intravenously or orally to rats. In the docetaxel-loaded solid SNEDDS prepared with colloidal silica, the liquid SNEDDS composed of Capryol 90, Cremophore EL and Transcutol HP (45/35/20, volume ratio) was absorbed inside the pores of carriers, and docetaxel was present in a changed amorphous state. The solid SNEDDS with 3.3% (w/v) docetaxel produced nanoemulsions, and showed about 12.5% absolute bioavailability in rats. Thus, this solid SNEDDS may be a potential candidate for oral pharmaceutical product with improved oral bioavailability of docetaxel.
ISSN:0265-2048
1464-5246
DOI:10.3109/02652048.2012.726280