Sedative activity in mice of a hydroalcohol extract of Hypericum perforatum L

The sedative activity of a hydroalcohol extract of Hypericum perforatum L. (Hypericaceae) and some of its isolated constituents was evaluated in mice. A dry hydroalcohol extract, orally administered at 26.5 mg/kg, induced a marked sedation as measured by two different tests (actimeter and sleep pote...

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Bibliographic Details
Published in:Phytotherapy research 1997-08, Vol.11 (5), p.395-397
Main Authors: Gîrzu, Mihaela, Carnat, Andrée, Privat, Anne-Marie, Fialip, Joseph, Carnat, André-Paul, Lamaison, Jean-Louis
Format: Article
Language:English
Subjects:
Biological and medical sciences
General pharmacology
hypericin separation
Hypericum perforatum L. hydroalcohol extract
Medical sciences
mice motivity
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
sedative activity
sleep potentiation
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Summary:The sedative activity of a hydroalcohol extract of Hypericum perforatum L. (Hypericaceae) and some of its isolated constituents was evaluated in mice. A dry hydroalcohol extract, orally administered at 26.5 mg/kg, induced a marked sedation as measured by two different tests (actimeter and sleep potentiation), compared with controls (diazepam, 2 mg/kg, per os). Several fractions were isolated from this hydroalcohol extract: hypericin, flavones, butanol fraction, aqueous fraction; a separation and purification method was developed for hypericin. None of the isolated fractions exhibited the same sedative activity as the hydroalcohol extract. © 1997 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/(SICI)1099-1573(199708)11:5<395::AID-PTR114>3.0.CO;2-Q