Sedative activity in mice of a hydroalcohol extract of Hypericum perforatum L

The sedative activity of a hydroalcohol extract of Hypericum perforatum L. (Hypericaceae) and some of its isolated constituents was evaluated in mice. A dry hydroalcohol extract, orally administered at 26.5 mg/kg, induced a marked sedation as measured by two different tests (actimeter and sleep pote...

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Published in:Phytotherapy research 1997-08, Vol.11 (5), p.395-397
Main Authors: Gîrzu, Mihaela, Carnat, Andrée, Privat, Anne-Marie, Fialip, Joseph, Carnat, André-Paul, Lamaison, Jean-Louis
Format: Article
Language:English
Subjects:
Biological and medical sciences
General pharmacology
hypericin separation
Hypericum perforatum L. hydroalcohol extract
Medical sciences
mice motivity
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
sedative activity
sleep potentiation
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container_issue 5
container_start_page 395
container_title Phytotherapy research
container_volume 11
creator Gîrzu, Mihaela
Carnat, Andrée
Privat, Anne-Marie
Fialip, Joseph
Carnat, André-Paul
Lamaison, Jean-Louis
description The sedative activity of a hydroalcohol extract of Hypericum perforatum L. (Hypericaceae) and some of its isolated constituents was evaluated in mice. A dry hydroalcohol extract, orally administered at 26.5 mg/kg, induced a marked sedation as measured by two different tests (actimeter and sleep potentiation), compared with controls (diazepam, 2 mg/kg, per os). Several fractions were isolated from this hydroalcohol extract: hypericin, flavones, butanol fraction, aqueous fraction; a separation and purification method was developed for hypericin. None of the isolated fractions exhibited the same sedative activity as the hydroalcohol extract. © 1997 John Wiley & Sons, Ltd.
doi_str_mv 10.1002/(SICI)1099-1573(199708)11:5<395::AID-PTR114>3.0.CO;2-Q
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subjects Biological and medical sciences
General pharmacology
hypericin separation
Hypericum perforatum L. hydroalcohol extract
Medical sciences
mice motivity
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
sedative activity
sleep potentiation
title Sedative activity in mice of a hydroalcohol extract of Hypericum perforatum L
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