Evolution of HIV incubation times in AIDS patients

Since introduction of highly active antiretroviral therapy (HAART), the incidence of AIDS has gradually declined, although the incidence of HIV infection is largely unknown. We have studied a sample with 10,571 patients whose data were recorded by Spain's public health system, in the Andalusian...

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Bibliographic Details
Published in:AIDS care 2013-08, Vol.25 (8), p.1051-1061
Main Authors: Román-Montoya, Y., Bueno-Cavanillas, A., Lara-Porras, A.M.
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - epidemiology
Acquired Immunodeficiency Syndrome - transmission
Adult
Age Distribution
AIDS
AIDS/HIV
Antiretroviral drugs
Antiretroviral therapy
Biological and medical sciences
Cox model
Disease transmission
Drug use
Drugs
Evolution
Female
Gender
HAART
Health policy
Heterosexuals
HIV
HIV Infections - epidemiology
HIV Infections - transmission
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Incidence
incubation time
Infectious Disease Incubation Period
Infectious diseases
Intravenous drug addicts
Libraries
Male
Medical sciences
Medical service
Miscellaneous
Patients
Proportional Hazards Models
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Public health
Retrospective Studies
Risk
Risk Factors
Sex Distribution
Sexually transmitted diseases
Social psychiatry. Ethnopsychiatry
Spain
Spain - epidemiology
Survival
Survival Analysis
Therapy
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Women
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Summary:Since introduction of highly active antiretroviral therapy (HAART), the incidence of AIDS has gradually declined, although the incidence of HIV infection is largely unknown. We have studied a sample with 10,571 patients whose data were recorded by Spain's public health system, in the Andalusian Register of Cases of AIDS. The diagnoses correspond to the period January 1981 to June 2008. For this period, AIDS incubation times were analyzed by means of the survival and risk functions, using R survival and DTDA libraries. We have studied the evolution of incubation mean times according to specific variables from database. The obtained results show that the mean times of viral incubation presented a growing trend that was greater among women when the study was limited to heterosexual transmission. Stratifying by category of transmission, the longest incubation period was seen for intravenous drug users (IDU). Both gender and IDU transmission were associated with significantly greater survival without AIDS. In contrast, heterosexual transmission or pneumonia diagnosis were associated with lower survival without AIDS.
ISSN:0954-0121
1360-0451
DOI:10.1080/09540121.2012.748876