Evaluation of Some Protective Agents on Stability and Controlled Release of Oral Pharmaceutical Forms by Fluid Bed Technique

• Published in: Drug development and industrial pharmacy 1997, Vol.23 (8), p.817-826
• Main Authors: Prinderre, P., Cauture, E., Piccerelle, Ph, Kalantzis, G., Kaloustian, J., Joachim, J.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; General pharmacology; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments
• ISSN: 0363-9045; 1520-5762
• DOI: 10.3109/03639049709150552

Abstract A number of coating agents recommended for protection against humidity were evaluated on granules containing josamycin and paracetamol. The coating films were composed of Eudragit L30D, Eudragit RS30D, Sepifilm LP010, and Compritol 888 Ato and the granules were coated in afluidized bed. Coated granules were stored in a desiccator with a saturated humidity, and the amount of moisture uptake was determined as a function of the storage time. The low hygro-scopicity of drugs and granules allowed us to classify these agents according to their water vapor permeability. The results obtained showed significant differences, depending on the nature of the protective agents and the drugs. 2′hermal analysis study was realized to investigate the physico-chemical interactions between drugs, excipients, and the coating agents. Finally, the tablet dissolution curves obtained from coated granules showed that release differed with the nature of the coating agents.