Evaluation of Some Protective Agents on Stability and Controlled Release of Oral Pharmaceutical Forms by Fluid Bed Technique

Abstract A number of coating agents recommended for protection against humidity were evaluated on granules containing josamycin and paracetamol. The coating films were composed of Eudragit L30D, Eudragit RS30D, Sepifilm LP010, and Compritol 888 Ato and the granules were coated in afluidized bed. Coa...

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Published in:Drug development and industrial pharmacy 1997, Vol.23 (8), p.817-826
Main Authors: Prinderre, P., Cauture, E., Piccerelle, Ph, Kalantzis, G., Kaloustian, J., Joachim, J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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cited_by cdi_FETCH-LOGICAL-c377t-cf319a4d08a10fb0a9e153070bbf1d54377c3799613a5bdfb3d5b272f74375343
cites cdi_FETCH-LOGICAL-c377t-cf319a4d08a10fb0a9e153070bbf1d54377c3799613a5bdfb3d5b272f74375343
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container_title Drug development and industrial pharmacy
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creator Prinderre, P.
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description Abstract A number of coating agents recommended for protection against humidity were evaluated on granules containing josamycin and paracetamol. The coating films were composed of Eudragit L30D, Eudragit RS30D, Sepifilm LP010, and Compritol 888 Ato and the granules were coated in afluidized bed. Coated granules were stored in a desiccator with a saturated humidity, and the amount of moisture uptake was determined as a function of the storage time. The low hygro-scopicity of drugs and granules allowed us to classify these agents according to their water vapor permeability. The results obtained showed significant differences, depending on the nature of the protective agents and the drugs. 2′hermal analysis study was realized to investigate the physico-chemical interactions between drugs, excipients, and the coating agents. Finally, the tablet dissolution curves obtained from coated granules showed that release differed with the nature of the coating agents.
doi_str_mv 10.3109/03639049709150552
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subjects Biological and medical sciences
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
title Evaluation of Some Protective Agents on Stability and Controlled Release of Oral Pharmaceutical Forms by Fluid Bed Technique
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