Optimization of a New Filler/Binder for Direct Compression Using Central Composite Design

Abstract An experimental design, the Central Composite, was used for the optimization of a new filler/binder (Xylitab 200®) for direct compression, with aspirin as the model drug. The design consists of four independent variables filler/binder, drug, disintegrant, and compression force) in varying a...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 1997, Vol.23 (10), p.945-950
Main Authors: Cirunay, Jesusa Joyce N., Plaizier-vercammen, Jacqueline A.
Format: Article
Language:English
Subjects:
Analgesics
Biological and medical sciences
General pharmacology
Medical sciences
Neuropharmacology
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:Abstract An experimental design, the Central Composite, was used for the optimization of a new filler/binder (Xylitab 200®) for direct compression, with aspirin as the model drug. The design consists of four independent variables filler/binder, drug, disintegrant, and compression force) in varying amounts, and with crushing strength, friability, weight variation, disintegration time, and dissolution rate as response variables. Multiple regression in the form of a second-order polynomial was used to determine meaningful relationships. In this study, the amounts of compression force and disintegrant played an important role in controlling the response variables.
ISSN:0363-9045
1520-5762
DOI:10.3109/03639049709149145