SAFE HAVEN: The Cell Biology of Nonfusogenic Pathogen Vacuoles

Our understanding of both membrane traffic in mammalian cells and the cell biology of infection with intracellular pathogens has increased dramatically in recent years. In this review, we discuss the cell biology of the host-microbe interaction for four intracellular pathogens: Chlamydia spp., Legio...

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Bibliographic Details
Published in:Annual review of microbiology 1997-01, Vol.51 (1), p.415-462
Main Authors: Sinai, Anthony P, Joiner, Keith A
Format: Article
Language:English
Subjects:
Analysis
Animals
Bacteria
Biological and medical sciences
Biological Transport
Cell Membrane - metabolism
Cellular biology
Chlamydia
Chlamydia - growth & development
Chlamydia - metabolism
Chlamydia - pathogenicity
Chlamydia Infections - metabolism
Cytology
Endocytosis
Fundamental and applied biological sciences. Psychology
General aspects
Host-Parasite Interactions
Host-parasite relationships
Legionella
Legionella pneumophila - growth & development
Legionella pneumophila - metabolism
Legionella pneumophila - pathogenicity
Legionnaires' Disease - metabolism
Microbiology
Mycobacterium
Mycobacterium - growth & development
Mycobacterium - metabolism
Mycobacterium - pathogenicity
Mycobacterium Infections - metabolism
Organelles - metabolism
Pathogenic microorganisms
Pathogens
Phagosomes - metabolism
Sexually transmitted diseases
STD
Toxoplasma
Toxoplasma - growth & development
Toxoplasma - metabolism
Toxoplasma - pathogenicity
Toxoplasmosis - metabolism
Vacuoles - metabolism
Vacuoles - physiology
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Summary:Our understanding of both membrane traffic in mammalian cells and the cell biology of infection with intracellular pathogens has increased dramatically in recent years. In this review, we discuss the cell biology of the host-microbe interaction for four intracellular pathogens: Chlamydia spp., Legionella pneumophila, Mycobacterium spp., and the protozoan parasite Toxoplasma gondii. All of these organisms reside in vacuoles inside cells that have restricted fusion with host organelles of the endocytic cascade. Despite this restricted fusion, the vacuoles surrounding each pathogen display novel interactions with other host cell organelles. In addition to the effect of infection on host membrane traffic, we focus on these novel interactions and relate them where possible to nutrient acquisition by the intracellular organisms.
ISSN:0066-4227
1545-3251
DOI:10.1146/annurev.micro.51.1.415