Methods for determining n-octanol-water partition constants

A short overview of methods for measuring n-octanol-water partition constants is given. The different methods are briefly described in terms of working principles, evaluation methods and ranges of applicability. Special emphasis is put on a critical consideration of their practicability for screenin...

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Bibliographic Details
Published in:TrAC, Trends in analytical chemistry (Regular ed.) Trends in analytical chemistry (Regular ed.), 1996, Vol.15 (4), p.188-196
Main Authors: Danielsson, Lars-Go¨ran, Zhang, Yu-Hui
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
General and physical chemistry
Solution properties
Solutions
Online Access:Get full text
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Summary:A short overview of methods for measuring n-octanol-water partition constants is given. The different methods are briefly described in terms of working principles, evaluation methods and ranges of applicability. Special emphasis is put on a critical consideration of their practicability for screening purposes.
ISSN:0165-9936
1879-3142
DOI:10.1016/0165-9936(96)00003-9