Effects of Colipase, Bile Salts, Na+, and Ca2+ on Pancreatic Lipase Activity

Unlike Borgström's theory that pancreatic colipase overcame the inhibition of pancreatic lipase activity caused by bile salts in tributyrin, pancreatic lipase activity in triolein was activated by bile salts and synergistically accelerated by colipase in the presence of NaCl and CaCl 2 . This f...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1994, Vol.58 (11), p.2121-2122
Main Authors: Naka, Yasuhiro, Nakamura, Teruo
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Hydrolases
Online Access:Get full text
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Summary:Unlike Borgström's theory that pancreatic colipase overcame the inhibition of pancreatic lipase activity caused by bile salts in tributyrin, pancreatic lipase activity in triolein was activated by bile salts and synergistically accelerated by colipase in the presence of NaCl and CaCl 2 . This finding reflected more closely the behavior of pancreatic lipase by using triolein as a representative dietary fat.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.58.2121