γδ T Cells And Acute Primary Toxoplasma gondii Infection In Mice

A murine model of Toxoplasma gondiiinfection was used to investigate whether ãα T cells are required to resist primary acute toxoplasmosis. The surface phenotype of peritoneal exudate and spleen cells obtained from T. gondii-infected mice was examined using anti- ãα T cell-specific reagents and flow...

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-01, Vol.171 (1), p.249-252
Main Authors: Sayles, Peter C., Rakhmilevich, Alexander L., Johnson, Lawrence L.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Concise Communications
Human mycoses
Immunoglobulins
Infections
Infectious diseases
Medical sciences
Mice
Monoclonal antibodies
Mycoses
Mycoses of the osteoarticular system
Natural killer cells
Spleen
Spleen cells
T cell antigen receptors
T lymphocytes
Toxoplasmosis
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Summary:A murine model of Toxoplasma gondiiinfection was used to investigate whether ãα T cells are required to resist primary acute toxoplasmosis. The surface phenotype of peritoneal exudate and spleen cells obtained from T. gondii-infected mice was examined using anti- ãα T cell-specific reagents and flow cytometry. Survival of mice depleted of ãα T cells was also followed during the acute phase of toxoplasmosis. Numbers of ãα T cells did not increase in spleen or peritoneal exudates of mice infected with T. gondii.Moreover, infected mice depleted of ãα T cells survived as long as untreated infected mice. These results indicate that ãα T cells do not play an important role in host defense against T. gondii infection in mice.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/171.1.249