Maternal Rescue of Transforming Growth Factor-β1 Null Mice

Maternal sources of transforming growth factor-β1 (TGF-β1) are shown here to contribute to the normal appearance and perinatal survival of TGF-β1 null newborn mice. Labeled TGF-β1 crossed the placenta and was recovered intact from various tissues after oral administration to mouse pups. TGFβ-1 prote...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1994-06, Vol.264 (5167), p.1936-1938
Main Authors: Letterio, John J., Geiser, Andrew G., Kulkarni, Ashok B., Roche, Nanette S., Sporn, Michael B., Roberts, Anita B.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chondrocytes
Classical genetics, quantitative genetics, hybrids
Fetus
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Heterozygotes
Liver
Lungs
Lymphocytes
Magnification
Mice
Muscles
Placenta
Vertebrata
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Summary:Maternal sources of transforming growth factor-β1 (TGF-β1) are shown here to contribute to the normal appearance and perinatal survival of TGF-β1 null newborn mice. Labeled TGF-β1 crossed the placenta and was recovered intact from various tissues after oral administration to mouse pups. TGFβ-1 protein was also detected in cells recovered from breast milk. In immunohistochemical analyses, TGF-β1 null embryos and null newborn pups born to TGF-β1 heterozygotes stained positive for TGF-β1, whereas those born to a null female were negative and had severe cardiac abnormalities. These results suggest an important role for maternal sources of TGF-β1 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.8009224