Central Nervous System Effects of Human Immunodeficiency Virus Type 1

Following its early entry into the central nervous system (CNS), HIV-1 alters cerebral cell architecture and may subsequently affect higher cognitive functions, leading eventually in some patients to HIV-1 encephalopathy. The CNS may also be the target of opportunistic infections and malignancy seco...

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Bibliographic Details
Published in:Annual review of medicine 1990-01, Vol.41 (1), p.159-168
Main Authors: Bridge, T P, Ingraham, L J
Format: Article
Language:English
Subjects:
AIDS Dementia Complex - drug therapy
AIDS Dementia Complex - epidemiology
AIDS Dementia Complex - etiology
AIDS/HIV
Biological and medical sciences
HIV-1
Humans
Immunopathology
Incidence
Medical sciences
United States - epidemiology
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Summary:Following its early entry into the central nervous system (CNS), HIV-1 alters cerebral cell architecture and may subsequently affect higher cognitive functions, leading eventually in some patients to HIV-1 encephalopathy. The CNS may also be the target of opportunistic infections and malignancy secondary to HIV-1 immunosuppression. Studies at the cellular, anatomical, and behavioral levels present evidence for significant involvement of the CNS in HIV-1 disease, while initial reports of treatment strategies hold promise for providing some amelioration in affected individuals.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.me.41.020190.001111