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Intestinal, Segmented, Filamentous Bacteria and Colonisation Resistance of Mice to Pathogenic Bacteria
We examined the possibility that segmented, filamentous bacteria (FBs) in the ileum of mice play a role in host resistance to pathogens by comparing four groups of mice, namely germ-free mice, mice mono-associated with FBs, FB-free mice with a specified pathogen-free (SPF) flora, and FB-positive SPF...
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Published in: | Microbial ecology in health and disease 1992, Vol.5 (6), p.299-307 |
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container_title | Microbial ecology in health and disease |
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creator | Klaasen, H. L. B. M. Koopman, J. P. Poelma, F. G. J. Van Den Brink, M. E. Barker, M. H. Beynen, A. C. |
description | We examined the possibility that segmented, filamentous bacteria (FBs) in the ileum of mice play a role in host resistance to pathogens by comparing four groups of mice, namely germ-free mice, mice mono-associated with FBs, FB-free mice with a specified pathogen-free (SPF) flora, and FB-positive SPF mice, after oral administration of viable cells of either Salmonella enteritidis or Enterobacter cloacae. The SPF gut flora with or without FBs reduced colonisation of host tissues by pathogens to a similar extent. FBs alone did not reduce mean colonisation, except for salmonella counts in spleen. Mice mono associated with FBs had a lower incidence of animals with salmonella-positive livers and spleens than did germ-free mice. When compared with the germ-free status, both the SPF flora and FBs raised the serum IgA concentration irrespective of the type of pathogen challenge. The SPF flora consistently raised the concanavalin A-induced proliferative response of isolated mesenteric lymph node cells (MLNC). In MLNC from FB-positive SPF mice, the concanavalin A-induced proliferative response was lower than in FB-free SPF mice, but the salmonella antigen-induced response of spleen cells (SC) was higher; these effects were independent of the type of pathogen challenge. The in vitro proliferative response of Peyer's patch cells to various antigens was not affected by the type of gut flora of mice challenged with either Salmonella enteritidis or Enterobacter cloacae. |
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L. B. M. ; Koopman, J. P. ; Poelma, F. G. J. ; Van Den Brink, M. E. ; Barker, M. H. ; Beynen, A. C.</creator><creatorcontrib>Klaasen, H. L. B. M. ; Koopman, J. P. ; Poelma, F. G. J. ; Van Den Brink, M. E. ; Barker, M. H. ; Beynen, A. C.</creatorcontrib><description>We examined the possibility that segmented, filamentous bacteria (FBs) in the ileum of mice play a role in host resistance to pathogens by comparing four groups of mice, namely germ-free mice, mice mono-associated with FBs, FB-free mice with a specified pathogen-free (SPF) flora, and FB-positive SPF mice, after oral administration of viable cells of either Salmonella enteritidis or Enterobacter cloacae. The SPF gut flora with or without FBs reduced colonisation of host tissues by pathogens to a similar extent. FBs alone did not reduce mean colonisation, except for salmonella counts in spleen. Mice mono associated with FBs had a lower incidence of animals with salmonella-positive livers and spleens than did germ-free mice. When compared with the germ-free status, both the SPF flora and FBs raised the serum IgA concentration irrespective of the type of pathogen challenge. The SPF flora consistently raised the concanavalin A-induced proliferative response of isolated mesenteric lymph node cells (MLNC). In MLNC from FB-positive SPF mice, the concanavalin A-induced proliferative response was lower than in FB-free SPF mice, but the salmonella antigen-induced response of spleen cells (SC) was higher; these effects were independent of the type of pathogen challenge. 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L. B. M.</creatorcontrib><creatorcontrib>Koopman, J. P.</creatorcontrib><creatorcontrib>Poelma, F. G. J.</creatorcontrib><creatorcontrib>Van Den Brink, M. E.</creatorcontrib><creatorcontrib>Barker, M. H.</creatorcontrib><creatorcontrib>Beynen, A. C.</creatorcontrib><title>Intestinal, Segmented, Filamentous Bacteria and Colonisation Resistance of Mice to Pathogenic Bacteria</title><title>Microbial ecology in health and disease</title><description>We examined the possibility that segmented, filamentous bacteria (FBs) in the ileum of mice play a role in host resistance to pathogens by comparing four groups of mice, namely germ-free mice, mice mono-associated with FBs, FB-free mice with a specified pathogen-free (SPF) flora, and FB-positive SPF mice, after oral administration of viable cells of either Salmonella enteritidis or Enterobacter cloacae. The SPF gut flora with or without FBs reduced colonisation of host tissues by pathogens to a similar extent. FBs alone did not reduce mean colonisation, except for salmonella counts in spleen. Mice mono associated with FBs had a lower incidence of animals with salmonella-positive livers and spleens than did germ-free mice. When compared with the germ-free status, both the SPF flora and FBs raised the serum IgA concentration irrespective of the type of pathogen challenge. The SPF flora consistently raised the concanavalin A-induced proliferative response of isolated mesenteric lymph node cells (MLNC). In MLNC from FB-positive SPF mice, the concanavalin A-induced proliferative response was lower than in FB-free SPF mice, but the salmonella antigen-induced response of spleen cells (SC) was higher; these effects were independent of the type of pathogen challenge. 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Psychology</subject><subject>Microbiology</subject><subject>Mouse intestine</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Salmonella</subject><subject>Segmented filamentous bacteria</subject><subject>Translocation</subject><issn>0891-060X</issn><issn>1651-2235</issn><issn>1651-2235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><recordid>eNp9kUtLQzEQhYMoWKs_wF0W4sqryc2jvehGi4-CovgAd5e5aWIjaaJJivjvTakWRHA1GXK-mZwThHYpOWSUNEdk2FAiSVOThnIqBF1DPSoFreqaiXXUW9xXRfC8ibZSeiWE1JzyHjJjn3XK1oM7wA_6ZaZLPznAF9bB4hzmCZ-ByjpawOAneBRc8DZBtsHje51syuCVxsHgG1tqDvgO8jS8aG_VCt1GGwZc0jvftY-eLs4fR1fV9e3leHR6XSkmh7SSdKAklx0bcgOyNkooCh3noAeyk7KpSwfSDAUTUtSia7QYUMEabVjHJ6JjfbS_nPsWw_u8GGtnNintHHhdrLRU8ropKRUhXQpVDClFbdq3aGcQP1tK2kWi7Z9EC7P3PRySAmdiMW7TCuSCcc5ZkZ0sZdabEGfwEaKbtBk-XYg_DPtvy_EvfKrB5amCqNvXMI_lo9I_b_wCxhSayg</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Klaasen, H. L. B. M.</creator><creator>Koopman, J. P.</creator><creator>Poelma, F. G. J.</creator><creator>Van Den Brink, M. E.</creator><creator>Barker, M. H.</creator><creator>Beynen, A. C.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>0YH</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>1992</creationdate><title>Intestinal, Segmented, Filamentous Bacteria and Colonisation Resistance of Mice to Pathogenic Bacteria</title><author>Klaasen, H. L. B. M. ; Koopman, J. P. ; Poelma, F. G. J. ; Van Den Brink, M. E. ; Barker, M. H. ; Beynen, A. 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J.</creatorcontrib><creatorcontrib>Van Den Brink, M. E.</creatorcontrib><creatorcontrib>Barker, M. H.</creatorcontrib><creatorcontrib>Beynen, A. C.</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Microbial ecology in health and disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klaasen, H. L. B. M.</au><au>Koopman, J. P.</au><au>Poelma, F. G. J.</au><au>Van Den Brink, M. E.</au><au>Barker, M. H.</au><au>Beynen, A. 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FBs alone did not reduce mean colonisation, except for salmonella counts in spleen. Mice mono associated with FBs had a lower incidence of animals with salmonella-positive livers and spleens than did germ-free mice. When compared with the germ-free status, both the SPF flora and FBs raised the serum IgA concentration irrespective of the type of pathogen challenge. The SPF flora consistently raised the concanavalin A-induced proliferative response of isolated mesenteric lymph node cells (MLNC). In MLNC from FB-positive SPF mice, the concanavalin A-induced proliferative response was lower than in FB-free SPF mice, but the salmonella antigen-induced response of spleen cells (SC) was higher; these effects were independent of the type of pathogen challenge. 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subjects | Bacteriology Biological and medical sciences Colonisation resistance Entero-pathogens Enterobacter Fundamental and applied biological sciences. Psychology Microbiology Mouse intestine Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Salmonella Segmented filamentous bacteria Translocation |
title | Intestinal, Segmented, Filamentous Bacteria and Colonisation Resistance of Mice to Pathogenic Bacteria |
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