SHIN, a Low Frequency Red Cell Antigen, Found in Two Japanese Blood Donors

A low frequency red cell antigen, SHIN, was detected in two Japanese blood donors. Red cells of the first propositus reacted, in pretransfusion tests, with the serum of a previously untransfused male patient. The second propositus was disclosed when anti-SHIN was used to screen red cells from 3,000...

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Bibliographic Details
Published in:Human heredity 1993-03, Vol.43 (2), p.69-73
Main Authors: Nakajima, H., Satoh, H., Komatsu, F., Green, C.A., Tippett, P., Lubenko, A.
Format: Article
Language:English
Subjects:
Antigens
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Blood Donors
Blood group antigens
Blood Group Antigens - blood
Blood Group Antigens - genetics
Blood Group Antigens - immunology
Erythrocytes - immunology
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes, Dominant
Genetic Linkage
Humans
Immunophenotyping
Japan
Male
Middle Aged
Molecular immunology
Original Paper
Pedigree
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Summary:A low frequency red cell antigen, SHIN, was detected in two Japanese blood donors. Red cells of the first propositus reacted, in pretransfusion tests, with the serum of a previously untransfused male patient. The second propositus was disclosed when anti-SHIN was used to screen red cells from 3,000 random blood donors in Tokyo: a frequency of 0.03% in this population. Family studies showed SHIN to be inherited as an autosomal dominant character and not to be part of the MNS, FY, JK or P₁ blood group systems. Anti-SHIN is not a common antibody in normal sera but was found in about 10% of multispecific sera used in investigation of low frequency antigens.
ISSN:0001-5652
1423-0062
DOI:10.1159/000154119