The protecting effect of L‐carnitine on Ca2+‐loaded rat liver mitochondria

It is shown that L‐carnitine strongly increases the ability of rat liver mitochondria to respond to the train of Ca2+ additions by a transient stimulation of the State‐4 respiration rate. Such an effect requires ATP and the L‐carnitine efficiency strongly decreases when ATP is omitted, Oleate influe...

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Bibliographic Details
Published in:FEBS letters 1991-09, Vol.289 (2), p.187-189
Main Authors: Mokhova, E., Arrigoni-Martelli, E., Bellei, M., Dedukhova, V., Muscatello, U., Starkov, A., Bobyleva, V.
Format: Article
Language:English
Subjects:
2,4-dinitrophenol
Acyl-CoA
Biological and medical sciences
bovine serum albumin
BSA
Ca2
Carnitine
Cell structures and functions
DNP
Fatty acid
FCCP
Fundamental and applied biological sciences. Psychology
Mitochondria and cell respiration
Mitochondrion
Molecular and cellular biology
MOPS
morpholinopropane sulphonate
p-trifluoromethoxycarbonylcyanide phenylhydrazone
Uncoupler
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Summary:It is shown that L‐carnitine strongly increases the ability of rat liver mitochondria to respond to the train of Ca2+ additions by a transient stimulation of the State‐4 respiration rate. Such an effect requires ATP and the L‐carnitine efficiency strongly decreases when ATP is omitted, Oleate influences the mitochondria in a fashion opposite to that of L‐carnitine. The oleate effect is strongly diminished by L‐carnitine. Again, the L‐carnitine effect requires ATP, and D‐carnitine fails to substitute for L‐carnitine. It is suggested that L‐carnitine removes, in an ATP‐dependent manner, endogenous or added fatty acids, which are involved in oxidative damage of Ca2+‐loaded mitochondria.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(91)81066-H