Haptoglobin Phenotypes in Diabetes mellitus and Diabetic Retinopathy

An analysis of haptoglobin (HP) phenotypes in 81 cases of diabetes mellitus (DM) without retinopathy and 122 cases with diabetic retinopathy (DR) were studied in relation to 180 normal and healthy controls matched for age and sex. A significant decrease in HP 2-1 frequency was found, suggesting prot...

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Bibliographic Details
Published in:Human heredity 1991, Vol.41 (5), p.347-350
Main Authors: Chandra, Tanuja, Lakshmi, C.N., Padma, T., Vidyavathi, M., Satapathy, M.
Format: Article
Language:English
Subjects:
Alleles
Associated diseases and complications
Biological and medical sciences
Diabetes Mellitus - genetics
Diabetes. Impaired glucose tolerance
Diabetic Retinopathy - genetics
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Gene Frequency - genetics
Haptoglobins - genetics
Humans
Male
Medical sciences
Original Paper
Original Papers
Phenotype
Sex Characteristics
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Summary:An analysis of haptoglobin (HP) phenotypes in 81 cases of diabetes mellitus (DM) without retinopathy and 122 cases with diabetic retinopathy (DR) were studied in relation to 180 normal and healthy controls matched for age and sex. A significant decrease in HP 2-1 frequency was found, suggesting protection for hétérozygotes in both DM and DR (with a relative risk of about 0.31). As an acute-phase reactant HP may be functionally involved in the etiology of DM and DR, which are associated with immunologic and inflammatory processes, respectively. No significant differences were found with respect to sex, age at onset, duration of DR, types of DM and DR, and family history.
ISSN:0001-5652
1423-0062
DOI:10.1159/000154023