Serum Paraoxonase Polymorphism in Three Populations of Southeast Asia

Serum paraoxonase hydrolyzes paraoxon, the principal metabolite of the insecticide parathion. Serum paraoxonase is polymorphic and controlled by two codominant alleles - PON*A and PON*B representing low and high activity, respectively. Three populations of southeast Asia comprising 194 Chinese, 159...

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Bibliographic Details
Published in:Human heredity 1991, Vol.41 (4), p.265-269
Main Authors: Roy, A.C., Saha, N., Tay, J.S.H., Ratnam, S.S.
Format: Article
Language:English
Subjects:
Aryldialkylphosphatase
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Hydrogen-Ion Concentration
Original Paper
Original Papers
Phosphoric Monoester Hydrolases - blood
Phosphoric Monoester Hydrolases - genetics
Polymorphism, Genetic - genetics
Population genetics, reproduction patterns
Singapore - ethnology
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Summary:Serum paraoxonase hydrolyzes paraoxon, the principal metabolite of the insecticide parathion. Serum paraoxonase is polymorphic and controlled by two codominant alleles - PON*A and PON*B representing low and high activity, respectively. Three populations of southeast Asia comprising 194 Chinese, 159 Filipinos and 73 Dravidian Indians were investigated for serum paraoxonase polymorphism. The frequency of PON*B was found to be 0.14 in the Chinese, 0.04 in the Filipinos and 0.18 in Dravidian Indians. The distribution of the PON phenotypes was at Hardy-Weinberg equilibrium in all the three populations studied.
ISSN:0001-5652
1423-0062
DOI:10.1159/000154010