Testis-/Embryo-Expressed Genes are Clustered in the Mouse H-2K Region

The major histocompatibility complex (MHC) of the mouse is located on chromosome 17 in the distal inversion of the t complex. In addition to genes playing major roles in the immune response, it contains a diversity of genes. In humans, numerous diseases are known to be associated with the MHC loci....

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1992-01, Vol.89 (2), p.773-777
Main Authors: Yeom, Young Il, Abe, Kuniya, Bennett, Dorothea, Artzt, Karen
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blotting, Northern
Blotting, Southern
Cell lines
Chromosome Mapping
Chromosomes
Complementary DNA
Fundamental and applied biological sciences. Psychology
Gels
Gene Expression
Genes
Genes, MHC Class I - genetics
Genes. Genome
Genetic Linkage
Genetics
Genomics
Germ cells
Haplotypes
Libraries
Major Histocompatibility Complex
Male
Mice - embryology
Mice - genetics
Molecular and cellular biology
Molecular genetics
Restriction Mapping
RNA, Messenger - genetics
Testes
Testis - physiology
Transcription, Genetic
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Summary:The major histocompatibility complex (MHC) of the mouse is located on chromosome 17 in the distal inversion of the t complex. In addition to genes playing major roles in the immune response, it contains a diversity of genes. In humans, numerous diseases are known to be associated with the MHC loci. Moreover, at least three recessive embryonic t-lethal mutations have been mapped to the MHC. Here a molecular genetic approach was used to study the detailed genomic structure of 240 kilobases (kb) surrounding the H-2K gene and 150 kb of a partly homologous region located in the distal inversion of the t complex. Combined with previous findings, the H-2K region was found to contain an impressively high density of genes-12 transcription units in 240 kb. Surprisingly, virtually all of these genes are expressed in testis and/or embryos. The genomic organization of this region is contrasted with the 150 kb of the homologous area where only three genes and an endogenous retrovirus reside.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.89.2.773