Theoretical aspects of chiral separation in capillary electrophoresis: I. Initial evaluation of a model

A simple model for the separation of pairs of enantiomeric molecules in capillary electrophoresis is presented. The model shows that the degree of separation depends on the concentration of chiral selector, and that there is an optimum concentration. The size of the optimum concentration depends inv...

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Bibliographic Details
Published in:Journal of Chromatography A 1992-06, Vol.603 (1), p.235-241
Main Authors: Wren, Stephen A.C., Rowe, Raymond C.
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Other chromatographic methods
Online Access:Get full text
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Summary:A simple model for the separation of pairs of enantiomeric molecules in capillary electrophoresis is presented. The model shows that the degree of separation depends on the concentration of chiral selector, and that there is an optimum concentration. The size of the optimum concentration depends inversely on the affinity of the enantiomers for the chiral selector. The model is supported by experimental results using propranolol and β-cyclodextrins.
ISSN:0021-9673
DOI:10.1016/0021-9673(92)85366-2