Complement Phenotypes in Patients with Psoriasis

Phenotype frequencies for the complement proteins C4A, C4B, Bf (factor B) and C3 were performed for 49 Caucasian patients with psoriasis. The C4*A6 allele was present in 26.6% of the patients as compared to 5.4% of healthy regional Caucasian controls, p < 0.001, relative risk = 6.28. The C4*A6 al...

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Bibliographic Details
Published in:Human heredity 1989, Vol.39 (6), p.327-332
Main Authors: Wyatt, Robert J., Wang, Can, Hudson, Edmund C., Jones, R. MacNeely, Noah, Patricia W., Rosenberg, E. William
Format: Article
Language:English
Subjects:
Biological and medical sciences
Complement C3 - genetics
Complement C4 - genetics
Complement C4a - genetics
Complement C4b - genetics
Complement Factor B - genetics
Complement System Proteins - genetics
Dermatology
European Continental Ancestry Group
Gene Frequency
Humans
Medical sciences
Original Paper
Original Papers
Phenotype
Psoriasis - genetics
Psoriasis. Parapsoriasis. Lichen
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Summary:Phenotype frequencies for the complement proteins C4A, C4B, Bf (factor B) and C3 were performed for 49 Caucasian patients with psoriasis. The C4*A6 allele was present in 26.6% of the patients as compared to 5.4% of healthy regional Caucasian controls, p < 0.001, relative risk = 6.28. The C4*A6 allele is known to be in linkage disequilibrium with the HLA B17 allele and to produce a non-functional gene product when it occurs with the B17 allele. HLA B17 is known to be associated with psoriasis in many Caucasian populations. Additional findings in the present study were a significant reduction in the C4B*2 allele frequency, a non-significant increase in the Bf*F allele frequency and no difference for Bf or C3 phenotype frequencies in the patients with psoriasis as compared to the controls.
ISSN:0001-5652
1423-0062
DOI:10.1159/000153884