Altered Controls of Proliferation in Proximal Small Intestine of the Senescent Rat

The proximal small intestine responds to starvation by rapidly reducing crypt cell proliferation rate and villus cellularity and to resumption of food intake (refeeding) by abruptly increasing proliferation and the number of villus epithelial cells. We show that villus cellularity responds to starva...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1988-04, Vol.85 (8), p.2771-2775
Main Authors: Holt, Peter R., Yeh, Kwo-Yih, Kotler, Donald P.
Format: Article
Language:English
Subjects:
Aging
Animals
Biological and medical sciences
Cell Division
Cell growth
Cellular senescence
Crypts
Duodenum
Epithelial cells
Food Deprivation
Fundamental and applied biological sciences. Psychology
Intestinal Mucosa - cytology
Intestinal Mucosa - enzymology
Intestine, Small - cytology
Intestine, Small - enzymology
Intestine. Mesentery
Jejunum
Rats
Rats, Inbred F344
Refeeding
Starvation
T tests
Thymidine Kinase - metabolism
Vertebrates: digestive system
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Summary:The proximal small intestine responds to starvation by rapidly reducing crypt cell proliferation rate and villus cellularity and to resumption of food intake (refeeding) by abruptly increasing proliferation and the number of villus epithelial cells. We show that villus cellularity responds to starvation and refeeding similarly in young and aging animals. However, as compared to young animals, senescent rats showed increased basal DNA synthetic activity, starvation resulted in a smaller decrease in DNA labeling of crypt cells, and refeeding produced an abrupt broadening of the proliferative zone in older animals without concomitant increased numbers of villus cells. Such altered crypt proliferative responses resemble precancerous changes seen in the colon and the aberrant proliferation found in both small and large intestine after administration of the carcinogen dimethylhydrazine.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.85.8.2771