The Formation of Reactive Oxygen Species Catalyzed by Neutral, Aqueous Extracts of NIST Ambient Particulate Matter and Diesel Engine Particles

It is important to characterize the chemical properties of particulate matter in order to understand how low doses, inhaled by a susceptible population, might cause human health effects. The formation of reactive oxygen species catalyzed by neutral, aqueous extracts of two ambient par-ticulate sampl...

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Bibliographic Details
Published in:Journal of the Air & Waste Management Association (1995) 2000-11, Vol.50 (11), p.1897-1903
Main Authors: Ball, James C., Straccia, Ann M., Young, Willie C., Aust, Ann E.
Format: Article
Language:English
Subjects:
Air Pollutants, Occupational - chemistry
Air Pollutants, Occupational - toxicity
Air. Soil. Water. Waste. Feeding
Applied sciences
Atmospheric pollution
Biological and medical sciences
Catalysis
Environment. Living conditions
Exact sciences and technology
Malondialdehyde - analysis
Mass Spectrometry
Medical sciences
Pollutants physicochemistry study: properties, effects, reactions, transport and distribution
Pollution
Public health. Hygiene
Public health. Hygiene-occupational medicine
Reactive Oxygen Species
Vehicle Emissions - analysis
Vehicle Emissions - toxicity
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Summary:It is important to characterize the chemical properties of particulate matter in order to understand how low doses, inhaled by a susceptible population, might cause human health effects. The formation of reactive oxygen species catalyzed by neutral, aqueous extracts of two ambient par-ticulate samples, National Institute of Standards & Technology (NIST) Standard Reference Materials (SRM) 1648 and 1649, and two diesel particulate samples, NIST SRM 1650 and SRM 2975, were measured. The formation of reactive oxygen species was estimated by measuring the formation of malondialdehyde from 2-deoxyribose in the presence of ascorbic acid; H 2 O 2 was not added to this assay. SRM 1649, ambient particulate matter collected from Washington, DC, generated the most malondialdehyde, while SRM 2975, diesel particulate matter collected from a forklift, yielded the least amount. Desferrioxamine inhibited the formation of malondialdehyde from the par-ticulate samples providing additional data to support the observation that transition metals were involved in the generation of reactive oxygen species. Six transition metal sulfates (iron sulfate, copper sulfate, vanadyl sulfate, cobalt sulfate, nickel sulfate, and zinc sulfate) were assayed
ISSN:1096-2247
2162-2906
DOI:10.1080/10473289.2000.10464231