Continuous enteral nutrition attenuates pulmonary edema in rats exposed to 100% oxygen

• Published in: Journal of applied physiology (1985) 2000-11, Vol.89 (5), p.1759-1765
• Main Authors: Factor, Phillip, Ridge, Karen, Alverdy, John, Sznajder, Jacob I
• Format: Article
• Language: English
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition; Enteral Nutrition; Gastrostomy; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase - metabolism; Hyperoxia - chemically induced; Hyperoxia - diet therapy; Hyperoxia - metabolism; Intensive care medicine; Lung - enzymology; Lungs; Male; Medical disorders; Medical sciences; Nutrition; Oxygen; Oxygen - toxicity; Pleural Effusion - chemically induced; Pleural Effusion - diet therapy; Pleural Effusion - metabolism; Pulmonary Edema - chemically induced; Pulmonary Edema - diet therapy; Pulmonary Edema - metabolism; Rats; Rats, Sprague-Dawley; RNA, Messenger - analysis; Rodents; Sodium-Potassium-Exchanging ATPase - genetics; Urine; Water - metabolism
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.2000.89.5.1759

1  Pulmonary and Critical Care Medicine, Evanston Northwestern Healthcare, Evanston 60201; 2  Northwestern University Medical School, Chicago 60611; and 3  Department of Surgery, University of Chicago, Chicago, Illinois 60616 Adult rats exposed to hyperoxia develop anorexia, weight loss, and a lung injury characterized by pulmonary edema and decreased lung liquid clearance. We hypothesized that maintenance of nutrition during hyperoxia could attenuate hyperoxia-induced pulmonary edema. To test this hypothesis, we enterally fed adult male Sprague-Dawley rats via gastrostomy tubes and exposed them to oxygen (inspired O 2 fraction >0.95) for 64 h. In contrast to controls, enterally fed hyperoxic animals did not lose weight and had smaller pleural effusions and wet-to-dry weight ratios (a measure of lung edema) that were not different from room air controls. Enterally fed rats exposed to hyperoxia had increased levels of mRNA for the Na + -K + -ATPase 1 - and 1 -subunits and glutathione peroxidase. These findings suggest that maintenance of nutrition during an oxidative lung injury reduces lung edema, perhaps by allowing for continued expression and function of protective proteins such as the Na + -K + -ATPase. sodium-potassium-adenosine 5'-triphosphatase; glutathione peroxidase; hyperoxia