Pituitary Follicular Cells Produce Basic Fibroblast Growth Factor

Cultured monolayers of bovine pituitary follicular cells, which transport ions, contain high amounts of mitogenic activity for endothelial cells which, on the basis of gene expression analysis, heparin-Sepharose elution profile, bioassay, immunoblotting, radioimmunoassay, and radioreceptor assay, ha...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1987-08, Vol.84 (16), p.5773-5777
Main Authors: Ferrara, Napoleone, Schweigerer, Lothar, Neufeld, Gera, Mitchell, Richard, Gospodarowicz, Denis
Format: Article
Language:English
Subjects:
Adrenal cortex
Animal cells
Animals
Antibodies
Biological and medical sciences
Cattle
Cell cultures. Hybridization. Fusion
Cell Differentiation
Cell Division
Cell extracts
Cell growth
Cell lines
Cells
Cells, Cultured
Cricetinae
Cultured cells
Endocrine cells
Endothelial cells
Fibroblast Growth Factors - biosynthesis
Fibroblast Growth Factors - genetics
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Nucleic Acid Hybridization
Pituitary Gland - cytology
Pituitary Gland - metabolism
RNA - analysis
Ungulates
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Summary:Cultured monolayers of bovine pituitary follicular cells, which transport ions, contain high amounts of mitogenic activity for endothelial cells which, on the basis of gene expression analysis, heparin-Sepharose elution profile, bioassay, immunoblotting, radioimmunoassay, and radioreceptor assay, has been identified as basic fibroblast growth factor (bFGF). These data indicate that follicular cells may be a major source of bFGF in the pituitary gland. Considering that bFGF has been proposed to play a role in paracrine regulation of pituitary hormone secretion, the data also suggest that these cells may exert important local regulatory functions.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.84.16.5773