Chromatographic behavior of diastereoisomers : VIII. Solvent selectivity effects in separations on silica

Solvent strength values and solvent selectivity effects have been studied for twenty diastereoisomers compounds (ten threo and erythro pairs) as a function of mobile phase composition, in thin-layer chromatography on silica. Forty-six different mobile phases were studied, composed of twelve differen...

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Bibliographic Details
Published in:Journal of Chromatography A 1986, Vol.354, p.107-118
Main Authors: Snyder, L.R., Palamareva, M.D., Kurtev, B.J., Viteva, L.Z., Stefanovsky, J.N.
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Other chromatographic methods
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Summary:Solvent strength values and solvent selectivity effects have been studied for twenty diastereoisomers compounds (ten threo and erythro pairs) as a function of mobile phase composition, in thin-layer chromatography on silica. Forty-six different mobile phases were studied, composed of twelve different solvents, and comprising almost 500 k′ values. These data are compared with predictions from a previous model and found to give generally good agreement between experiment and theory. The general importance of solvent—solute localization in determining changes in band-spacing (α-values) was confirmed.
ISSN:0021-9673
DOI:10.1016/S0021-9673(01)87015-1