THE USE OF CARBOXYMETHYL ETHOXYLATE SURFACTANT TO DISSOLVE VITAMIN K1 AND TO OBTAIN LOW INTERFACIAL TENSION AND STABLE EMULSION SYSTEMS

The presence of vitamin K 1 in human body is important for preventing the hemorrhagic disease. Due to its very long side chain, vitamin K 1 is highly insoluble in water. We have successfully dissolve a substantial amount of vitamin K 1 in solutions of a commercial surfactant containing carboxymethyl...

Full description

Saved in:
Bibliographic Details
Published in:Journal of dispersion science and technology 2000-01, Vol.21 (7), p.969-981
Main Authors: Chiu, Y.C., Huang, J.F., Feng, C.A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The presence of vitamin K 1 in human body is important for preventing the hemorrhagic disease. Due to its very long side chain, vitamin K 1 is highly insoluble in water. We have successfully dissolve a substantial amount of vitamin K 1 in solutions of a commercial surfactant containing carboxymethyl ethoxylates (Hüls B433) and obtained low interfacial tension (IFT) and stable emulsion systems. This paper will present the details of these experiments. The solubilization of vitamin K 1 was estimated from UV absorption. The IFT values were measured by using a spinning drop apparatus and all particle sizes were determined by using laser light scattering. By using the Hüls B433 surfactant and an optimum amount of CaCl 2 , we can dissolve vitamin K 1 in water and obtain low IFT systems in the order of 10 −2 dyne/cm. The emulsions obtained in these systems are stable and contain droplet sizes below 65 nm. The dissolution of vitamin K 1 and the IFT behavior in these systems follow the rules for crude oil and prefer larger surfactant micelles.
ISSN:0193-2691
1532-2351
DOI:10.1080/01932690008913324