Aldehyde Dehydrogenase Isozyme Deficiency and Alcohol Sensitivity in Four Different Chinese Populations

Four different populations of China were studied regarding aldehyde dehydrogenase isozyme variation and incidence of alcohol sensitivity. While Korean and Mongolian minorities in the north showed an isozyme I deficiency with a frequency of about 25 and 30%, 45-50% of Zhuang and Han were deficient, r...

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Bibliographic Details
Published in:Human heredity 1984, Vol.34 (3), p.183-186
Main Authors: Goedde, H.W., Benkmann, H.G., Kriese, L., Bogdanski, P., Agarwal, D.P., Ruofu, Du, Liangzhong, Chen, Meiying, Cui, Yida, Yuan, Jiujin, Xu, Shizhe, Li, Yongfa, Wang
Format: Article
Language:English
Subjects:
Aldehyde Dehydrogenase
Aldehyde Oxidoreductases - deficiency
Aldehyde Oxidoreductases - genetics
Asian Continental Ancestry Group
Biological and medical sciences
China
Ethanol - adverse effects
Ethanol - metabolism
Ethnic Groups
Flushing - chemically induced
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Isoenzymes - deficiency
Isoenzymes - genetics
Population genetics, reproduction patterns
Short Communication
Short Communications
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Summary:Four different populations of China were studied regarding aldehyde dehydrogenase isozyme variation and incidence of alcohol sensitivity. While Korean and Mongolian minorities in the north showed an isozyme I deficiency with a frequency of about 25 and 30%, 45-50% of Zhuang and Han were deficient, respectively. Adverse reactions after alcohol drinking were mainly reported by those subjects who showed the lack of aldehyde dehydrogenase isozyme I.
ISSN:0001-5652
1423-0062
DOI:10.1159/000153459