Interaction of α2‐macroglobulin‐bound thrombin with hirudin

The human thrombin bound to α2‐macroglobulin (α2 M) in a 1:1 stoichiometry is still able to interact with one of its specific inhibitors, hirudin. The dissociation constant of the complex hirudin‐α2M‐bound thrombin is 1 × 10−7 M, whatever the mode of thrombin binding, covalent or non‐covalent....

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Bibliographic Details
Published in:FEBS letters 1984-11, Vol.177 (1), p.109-111
Main Authors: Pochon, François, Steinbuch, Marion
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood coagulation. Blood cells
Coagulation factors
Fundamental and applied biological sciences. Psychology
Hirudin
Molecular and cellular biology
Thrombin
α2-Macroglobulin
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Summary:The human thrombin bound to α2‐macroglobulin (α2 M) in a 1:1 stoichiometry is still able to interact with one of its specific inhibitors, hirudin. The dissociation constant of the complex hirudin‐α2M‐bound thrombin is 1 × 10−7 M, whatever the mode of thrombin binding, covalent or non‐covalent.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(84)80991-6