Expression of p21ras in fresh primary and metastatic human colorectal tumors

Activation of the cellular oncogene ras has been implicated in many types of human malignancies. In this study, the relative levels of p21 protein product of ras (p21ras) in primary and metastatic colon tumors were compared to those in adjacent normal tissues. Nine of the 17 primary tumors had subst...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1985-03, Vol.82 (6), p.1795-1799
Main Authors: GALLICK, G. E, KURZROCK, R, KLOETZER, W. S, ARLINGHAUS, R. B, GUTTERMAN, J. U
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Colonic Neoplasms - genetics
Colonic Neoplasms - secondary
Female
Gene Expression Regulation
Humans
Male
Medical sciences
Middle Aged
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Oncogenes
Proto-Oncogene Proteins p21(ras)
Rectal Neoplasms - genetics
Rectal Neoplasms - secondary
Tumors
Viruses
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Summary:Activation of the cellular oncogene ras has been implicated in many types of human malignancies. In this study, the relative levels of p21 protein product of ras (p21ras) in primary and metastatic colon tumors were compared to those in adjacent normal tissues. Nine of the 17 primary tumors had substantially elevated levels of p21ras with respect to adjacent normal tissues. Eight of these tumors were from Dukes' B and C stages. Four of the five tumors classified as "D" stage (in which distant metastases are present) did not show elevated levels of p21ras. In metastases from primary colon tumors, nine of nine were considerably reduced in p21ras expression regardless of the site of metastasis. These data suggest that elevation of p21ras may be a common event in early stages of colon tumors, and tumor progression may lead to a more autonomous population of cells in which other growth factors supplant the role of this protein.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.82.6.1795