Population and Quantitative Genetics of Many Linked Loci in Finite Populations [and Discussion]

Theoretical studies on the effects of linkage on variability of quantitative traits and response to directional selection in finite populations are reviewed. Emphasis is given to predictions that can be based on observable parameters, such as population size, chromosome lengths and the increment in...

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Bibliographic Details
Published in:Proceedings of the Royal Society of London. Series B, Biological sciences Biological sciences, 1983-10, Vol.219 (1216), p.253-264
Main Authors: Robertson, A., Hill, W. G., Ewens, W. J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosomes
Fundamental and applied biological sciences. Psychology
Genetic loci
Genetic mutation
Genetic variance
Genetic variation
Genetics of eukaryotes. Biological and molecular evolution
Linkage disequilibrium
Population genetics
Population genetics, reproduction patterns
Population size
Quantitative genetics
Quantitative traits
Theories and miscellaneous
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Summary:Theoretical studies on the effects of linkage on variability of quantitative traits and response to directional selection in finite populations are reviewed. Emphasis is given to predictions that can be based on observable parameters, such as population size, chromosome lengths and the increment in variance from new mutations. Although truncation selection produces negative linkage disequilibrium in infinite populations, simulation results show that the effects of linkage on response are more pronounced in finite populations. Substantial linkage disequilibrium at the DNA sequence level is being found in population surveys. Some of the results and their interpretation are discussed.
ISSN:0962-8452
0080-4649
1471-2954
2053-9193
DOI:10.1098/rspb.1983.0073