Fructose Malabsorption is Associated with Decreased Plasma Tryptophan

Background: Fructose malabsorption is characterized by the inability to absorb fructose efficiently. As a consequence fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO2, H2, CH4 and lactic acid. Bloating, cramps, osmotic diarrhea and other symptoms of irritable...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2001-01, Vol.36 (4), p.367-371
Main Authors: LEDOCHOWSKI, M, WIDNER, B, MURR, C, SPERNER-UNTERWEGER, B, FUCHS, D
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
Aged
Biological and medical sciences
Breath Tests
Chromatography, High Pressure Liquid
Fasting
Female
Fructose - administration & dosage
Fructose - pharmacokinetics
Fructose Loading Test Fructose Malabsorption H2 Exhalation Tryptophan
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hydrogen-Ion Concentration
Malabsorption Syndromes - blood
Malabsorption Syndromes - diagnosis
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Reference Values
Sensitivity and Specificity
Statistics, Nonparametric
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tryptophan - blood
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Summary:Background: Fructose malabsorption is characterized by the inability to absorb fructose efficiently. As a consequence fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO2, H2, CH4 and lactic acid. Bloating, cramps, osmotic diarrhea and other symptoms of irritable bowel syndrome are the consequence and can be seen in about 50% of fructose malabsorbers. Recently it was found that fructose malabsorption was associated with early signs of depressive disorders. Therefore, it was investigated whether fructose malabsorption is associated with abnormal tryptophan metabolism. Methods: Fifty adults (16 men, 34 women) with gastrointestinal discomfort were analyzed by measuring breath hydrogen concentrations after an oral dose of 50 g fructose after an overnight fast. They were classified as normals or fructose malabsorbers according to their breath H2 concentrations. All patients filled out a Beck depression inventory questionnaire. Blood samples were taken for plasma tryptophan and kynurenine measurements. Results:
ISSN:0036-5521
1502-7708
DOI:10.1080/00365520117856