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Fructose Malabsorption is Associated with Decreased Plasma Tryptophan
Background: Fructose malabsorption is characterized by the inability to absorb fructose efficiently. As a consequence fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO2, H2, CH4 and lactic acid. Bloating, cramps, osmotic diarrhea and other symptoms of irritable...
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| Published in: | Scandinavian journal of gastroenterology 2001-01, Vol.36 (4), p.367-371 |
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| Main Authors: | , , , , |
| Format: | Article |
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| container_end_page | 371 |
| container_issue | 4 |
| container_start_page | 367 |
| container_title | Scandinavian journal of gastroenterology |
| container_volume | 36 |
| creator | LEDOCHOWSKI, M WIDNER, B MURR, C SPERNER-UNTERWEGER, B FUCHS, D |
| description | Background: Fructose malabsorption is characterized by the inability to absorb fructose efficiently. As a consequence fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO2, H2, CH4 and lactic acid. Bloating, cramps, osmotic diarrhea and other symptoms of irritable bowel syndrome are the consequence and can be seen in about 50% of fructose malabsorbers. Recently it was found that fructose malabsorption was associated with early signs of depressive disorders. Therefore, it was investigated whether fructose malabsorption is associated with abnormal tryptophan metabolism. Methods: Fifty adults (16 men, 34 women) with gastrointestinal discomfort were analyzed by measuring breath hydrogen concentrations after an oral dose of 50 g fructose after an overnight fast. They were classified as normals or fructose malabsorbers according to their breath H2 concentrations. All patients filled out a Beck depression inventory questionnaire. Blood samples were taken for plasma tryptophan and kynurenine measurements. Results: |
| doi_str_mv | 10.1080/00365520117856 |
| format | article |
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As a consequence fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO2, H2, CH4 and lactic acid. Bloating, cramps, osmotic diarrhea and other symptoms of irritable bowel syndrome are the consequence and can be seen in about 50% of fructose malabsorbers. Recently it was found that fructose malabsorption was associated with early signs of depressive disorders. Therefore, it was investigated whether fructose malabsorption is associated with abnormal tryptophan metabolism. Methods: Fifty adults (16 men, 34 women) with gastrointestinal discomfort were analyzed by measuring breath hydrogen concentrations after an oral dose of 50 g fructose after an overnight fast. They were classified as normals or fructose malabsorbers according to their breath H2 concentrations. All patients filled out a Beck depression inventory questionnaire. Blood samples were taken for plasma tryptophan and kynurenine measurements. Results:</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/00365520117856</identifier><identifier>PMID: 11336160</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>Administration, Oral ; Adolescent ; Adult ; Aged ; Biological and medical sciences ; Breath Tests ; Chromatography, High Pressure Liquid ; Fasting ; Female ; Fructose - administration & dosage ; Fructose - pharmacokinetics ; Fructose Loading Test Fructose Malabsorption H2 Exhalation Tryptophan ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Hydrogen-Ion Concentration ; Malabsorption Syndromes - blood ; Malabsorption Syndromes - diagnosis ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Reference Values ; Sensitivity and Specificity ; Statistics, Nonparametric ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tryptophan - blood</subject><ispartof>Scandinavian journal of gastroenterology, 2001-01, Vol.36 (4), p.367-371</ispartof><rights>2001 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2001</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2650-77fdaa966ec5dfd88671a138d456d8096cfe323c7eaae2a3027ae50e94482e8b3</citedby><cites>FETCH-LOGICAL-c2650-77fdaa966ec5dfd88671a138d456d8096cfe323c7eaae2a3027ae50e94482e8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=965403$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11336160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEDOCHOWSKI, M</creatorcontrib><creatorcontrib>WIDNER, B</creatorcontrib><creatorcontrib>MURR, C</creatorcontrib><creatorcontrib>SPERNER-UNTERWEGER, B</creatorcontrib><creatorcontrib>FUCHS, D</creatorcontrib><title>Fructose Malabsorption is Associated with Decreased Plasma Tryptophan</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Background: Fructose malabsorption is characterized by the inability to absorb fructose efficiently. As a consequence fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO2, H2, CH4 and lactic acid. Bloating, cramps, osmotic diarrhea and other symptoms of irritable bowel syndrome are the consequence and can be seen in about 50% of fructose malabsorbers. Recently it was found that fructose malabsorption was associated with early signs of depressive disorders. Therefore, it was investigated whether fructose malabsorption is associated with abnormal tryptophan metabolism. Methods: Fifty adults (16 men, 34 women) with gastrointestinal discomfort were analyzed by measuring breath hydrogen concentrations after an oral dose of 50 g fructose after an overnight fast. They were classified as normals or fructose malabsorbers according to their breath H2 concentrations. All patients filled out a Beck depression inventory questionnaire. Blood samples were taken for plasma tryptophan and kynurenine measurements. Results:</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breath Tests</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Fasting</subject><subject>Female</subject><subject>Fructose - administration & dosage</subject><subject>Fructose - pharmacokinetics</subject><subject>Fructose Loading Test Fructose Malabsorption H2 Exhalation Tryptophan</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Malabsorption Syndromes - blood</subject><subject>Malabsorption Syndromes - diagnosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Statistics, Nonparametric</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tryptophan - blood</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp1kE1P3DAQhq2qqCzQK8cqUqXeFsZx7DhHxLcEggOco1lnog1y4tSTCO2_r9EuRRw4WdY87-idR4hjCScSLJwCKKN1DlKWVptvYiE15MuyBPtdLN6GyzSV--KA-QUAdFlUP8S-lEoZaWAhLq_i7KbAlN2jxxWHOE5dGLKOszPm4DqcqMleu2mdXZCLhJy-jx65x-wpbsYpjGscjsRei57p5-49FM9Xl0_nN8u7h-vb87O7pcuNhlSrbRArY8jppm2sNaVEqWxTaNNYqIxrSeXKlYRIOSrISyQNVBWFzcmu1KH4s907xvB3Jp7qvmNH3uNAYeY6nS2TjiqBJ1vQxcAcqa3H2PUYN7WE-k1c_VlcCvzabZ5XPTUf-M5UAn7vAGSHvo04uI7_c5XRBahEVVuqG9oQe3wN0Tf1hBsf4ntEfVnBfsquCf20dhipfglzHJLYr9r_A_h4mHc</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>LEDOCHOWSKI, M</creator><creator>WIDNER, B</creator><creator>MURR, C</creator><creator>SPERNER-UNTERWEGER, B</creator><creator>FUCHS, D</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010101</creationdate><title>Fructose Malabsorption is Associated with Decreased Plasma Tryptophan</title><author>LEDOCHOWSKI, M ; WIDNER, B ; MURR, C ; SPERNER-UNTERWEGER, B ; FUCHS, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2650-77fdaa966ec5dfd88671a138d456d8096cfe323c7eaae2a3027ae50e94482e8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breath Tests</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Fasting</topic><topic>Female</topic><topic>Fructose - administration & dosage</topic><topic>Fructose - pharmacokinetics</topic><topic>Fructose Loading Test Fructose Malabsorption H2 Exhalation Tryptophan</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Malabsorption Syndromes - blood</topic><topic>Malabsorption Syndromes - diagnosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Reference Values</topic><topic>Sensitivity and Specificity</topic><topic>Statistics, Nonparametric</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tryptophan - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEDOCHOWSKI, M</creatorcontrib><creatorcontrib>WIDNER, B</creatorcontrib><creatorcontrib>MURR, C</creatorcontrib><creatorcontrib>SPERNER-UNTERWEGER, B</creatorcontrib><creatorcontrib>FUCHS, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEDOCHOWSKI, M</au><au>WIDNER, B</au><au>MURR, C</au><au>SPERNER-UNTERWEGER, B</au><au>FUCHS, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fructose Malabsorption is Associated with Decreased Plasma Tryptophan</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>36</volume><issue>4</issue><spage>367</spage><epage>371</epage><pages>367-371</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Background: Fructose malabsorption is characterized by the inability to absorb fructose efficiently. As a consequence fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO2, H2, CH4 and lactic acid. Bloating, cramps, osmotic diarrhea and other symptoms of irritable bowel syndrome are the consequence and can be seen in about 50% of fructose malabsorbers. Recently it was found that fructose malabsorption was associated with early signs of depressive disorders. Therefore, it was investigated whether fructose malabsorption is associated with abnormal tryptophan metabolism. Methods: Fifty adults (16 men, 34 women) with gastrointestinal discomfort were analyzed by measuring breath hydrogen concentrations after an oral dose of 50 g fructose after an overnight fast. They were classified as normals or fructose malabsorbers according to their breath H2 concentrations. All patients filled out a Beck depression inventory questionnaire. Blood samples were taken for plasma tryptophan and kynurenine measurements. Results:</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>11336160</pmid><doi>10.1080/00365520117856</doi><tpages>5</tpages></addata></record> |
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| ispartof | Scandinavian journal of gastroenterology, 2001-01, Vol.36 (4), p.367-371 |
| issn | 0036-5521 1502-7708 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_965403 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Administration, Oral Adolescent Adult Aged Biological and medical sciences Breath Tests Chromatography, High Pressure Liquid Fasting Female Fructose - administration & dosage Fructose - pharmacokinetics Fructose Loading Test Fructose Malabsorption H2 Exhalation Tryptophan Gastroenterology. Liver. Pancreas. Abdomen Humans Hydrogen-Ion Concentration Malabsorption Syndromes - blood Malabsorption Syndromes - diagnosis Male Medical sciences Middle Aged Other diseases. Semiology Reference Values Sensitivity and Specificity Statistics, Nonparametric Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tryptophan - blood |
| title | Fructose Malabsorption is Associated with Decreased Plasma Tryptophan |
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