Electric field stimulation of cardiac myocytes during postnatal development

Studies on cardiac cell response to electric field stimulation are important for understanding basic phenomena underlying cardiac defibrillation. In this work, the authors used a model of a prolate spheroidal cell in a uniform external field (Klee and Plonsey, 1976) to predict the threshold electric...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2001-06, Vol.48 (6), p.630-636
Main Authors: Gomes, P.A.P., Bassani, R.A., Bassani, J.W.M.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Animals, Newborn - physiology
Biological and medical sciences
Biomembranes
Cardiovascular system
Cell physiology
Cells
Defibrillation
Effects of physical and chemical agents
Electric field effects
Electric potential
Electric Stimulation
Electrophysiology
Functional assessment
Fundamental and applied biological sciences. Psychology
Geometry
Heart Ventricles - cytology
Image Processing, Computer-Assisted
Molecular and cellular biology
Neonatal monitoring
Pediatrics
Predictive models
Rats
Rats, Wistar
Shape
Solid modeling
Statistics, Nonparametric
Ventricular Function
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Summary:Studies on cardiac cell response to electric field stimulation are important for understanding basic phenomena underlying cardiac defibrillation. In this work, the authors used a model of a prolate spheroidal cell in a uniform external field (Klee and Plonsey, 1976) to predict the threshold electric field (ET) for stimulation of isolated ventricular myocytes of rats at different ages. The model assumes that ET is primarily determined by cell shape and dimensions, which markedly change during postnatal development. Neonatal cells showed very high ET, which progressively decreased with maturation (experimental mean values were 29, 21, 13, and 5.9 and 6.3 V/cm for 3-6, 13-16, 20-21, 28-35, and 120-180 day-old rats, respectively, P
ISSN:0018-9294
1558-2531
DOI:10.1109/10.923781