Neural growth factor expression in the lateral retinaculum in painful patellofemoral malalignment

We studied 7 samples of lateral retinaculae excised at the time of surgical realignments. They were obtained from patients with isolated symptomatic patellofemoral malalignment resistant to conservative treatment and were evaluated with immunohistochemistry and immunoblotting. We found that neural g...

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Bibliographic Details
Published in:Acta orthopaedica 2001, Vol.72 (2), p.146-149
Main Authors: Sanchis-Alfonso, Vicente, Roselló-Sastre, Esther, Revert, Fernando
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Diseases of the osteoarticular system
Female
Femur - chemistry
Femur - pathology
Femur - surgery
Gene Expression Regulation
Humans
Immunoblotting
Immunohistochemistry
Joint Instability - etiology
Joint Instability - metabolism
Joint Instability - pathology
Knee Joint - chemistry
Knee Joint - pathology
Knee Joint - surgery
Medical sciences
Miscellaneous. Osteoarticular involvement in other diseases
Nerve Growth Factors - analysis
Pain - etiology
Pain - metabolism
Pain - pathology
Patella - chemistry
Patella - pathology
Patella - surgery
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Summary:We studied 7 samples of lateral retinaculae excised at the time of surgical realignments. They were obtained from patients with isolated symptomatic patellofemoral malalignment resistant to conservative treatment and were evaluated with immunohistochemistry and immunoblotting. We found that neural growth factor is higher in patients with pain than in those with instability as the main symptom. Neural growth factor is related to neural proliferation in vessels and perivascular tissue and to the release of neuroceptive transmitters, such as substance P. We postulate that both mechanisms are involved in the pathogenesis of pain in isolated symptomatic patellofemoral malalignment.
ISSN:1745-3674
0001-6470
1745-3682
DOI:10.1080/000164701317323390