Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a serious systemic autoimmune disorder that affects multiple organ systems and is characterized by unpredictable flares of disease. Recent evidence indicates a role for type I interferon (IFN) in SLE pathogenesis; however, the downstream effects of IFN pathway a...

Full description

Saved in:
Bibliographic Details
Published in:PLoS medicine 2006-12, Vol.3 (12), p.e491-e491
Main Authors: Bauer, Jason W, Baechler, Emily C, Petri, Michelle, Batliwalla, Franak M, Crawford, Dianna, Ortmann, Ward A, Espe, Karl J, Li, Wentian, Patel, Dhavalkumar D, Gregersen, Peter K, Behrens, Timothy W
Format: Article
Language:English
Subjects:
Adult
Arthritis
Autoimmune diseases
Biomarkers
Biomarkers - blood
Blood
Case-Control Studies
Chemokines
Chemokines - blood
Chemokines - metabolism
Cytokines
Diagnosis
Disease
Female
Gene therapy
Genes
Genetics and Genomics
Humans
Immune system
Immunoassay
Immunology
Interferon
Interferon Type I - pharmacology
Lupus
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - metabolism
Lupus Erythematosus, Systemic - pathology
Male
Medical research
Observations
Patients
Proteins
Proteome - analysis
Proteomics - methods
Rheumatology
Systemic Lupus Erythematosus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Systemic lupus erythematosus (SLE) is a serious systemic autoimmune disorder that affects multiple organ systems and is characterized by unpredictable flares of disease. Recent evidence indicates a role for type I interferon (IFN) in SLE pathogenesis; however, the downstream effects of IFN pathway activation are not well understood. Here we test the hypothesis that type I IFN-regulated proteins are present in the serum of SLE patients and correlate with disease activity. We performed a comprehensive survey of the serologic proteome in human SLE and identified dysregulated levels of 30 cytokines, chemokines, growth factors, and soluble receptors. Particularly striking was the highly coordinated up-regulation of 12 inflammatory and/or homeostatic chemokines, molecules that direct the movement of leukocytes in the body. Most of the identified chemokines were inducible by type I IFN, and their levels correlated strongly with clinical and laboratory measures of disease activity. These data suggest that severely disrupted chemokine gradients may contribute to the systemic autoimmunity observed in human SLE. Furthermore, the levels of serum chemokines may serve as convenient biomarkers for disease activity in lupus.
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.0030491