Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): explanation and elaboration

The REMARK (Reporting Recommendations for Tumor Marker Prognostic Studies) guideline includes a checklist which aims to improve the reporting of these types of studies. Here, we expand on the REMARK checklist to enhance its use and effectiveness through better understanding of the intent of each ite...

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Bibliographic Details
Published in:PLoS medicine 2012-05, Vol.9 (5), p.e1001216-e1001216
Main Authors: Altman, Douglas G, McShane, Lisa M, Sauerbrei, Willi, Taube, Sheila E
Format: Article
Language:English
Subjects:
Biomarkers, Tumor
Biomedical Research - standards
Cancer
Checklist
Clinical trials
Diagnosis
Guidelines and Guidance
Guidelines as Topic
Humans
Medical research
Medicine
Neoplasms
Physiological aspects
Prognosis
Publishing - standards
Research Design - standards
Research Report
Science Policy
Studies
Tumor markers
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Summary:The REMARK (Reporting Recommendations for Tumor Marker Prognostic Studies) guideline includes a checklist which aims to improve the reporting of these types of studies. Here, we expand on the REMARK checklist to enhance its use and effectiveness through better understanding of the intent of each item and why the information is important to report. Each checklist item of the REMARK guideline is explained in detail and accompanied by published examples of good reporting. The paper provides a comprehensive overview to educate on good reporting and provide a valuable reference of issues to consider when designing, conducting, and analyzing tumor marker studies and prognostic studies in medicine in general.
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.1001216