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The impact of repeated rounds of mass drug administration with diethylcarbamazine plus albendazole on bancroftian filariasis in Papua New Guinea
This study employed various monitoring methods to assess the impact of repeated rounds of mass drug administration (MDA) on bancroftian filariasis in Papua New Guinea, which has the largest filariasis problem in the Pacific region. Residents of rural villages near Madang were studied prior to and on...
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| Published in: | PLoS neglected tropical diseases 2008-12, Vol.2 (12), p.e344-e344 |
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| container_end_page | e344 |
| container_issue | 12 |
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| container_title | PLoS neglected tropical diseases |
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| creator | Weil, Gary J Kastens, Will Susapu, Melinda Laney, Sandra J Williams, Steven A King, Christopher L Kazura, James W Bockarie, Moses J |
| description | This study employed various monitoring methods to assess the impact of repeated rounds of mass drug administration (MDA) on bancroftian filariasis in Papua New Guinea, which has the largest filariasis problem in the Pacific region.
Residents of rural villages near Madang were studied prior to and one year after each of three rounds of MDA with diethylcarbamazine plus albendazole administered per World Health Organization (WHO) guidelines. The mean MDA compliance rate was 72.9%. Three rounds of MDA decreased microfilaremia rates (Mf, 1 ml night blood by filter) from 18.6% pre-MDA to 1.3% after the third MDA (a 94% decrease). Mf clearance rates in infected persons were 71%, 90.7%, and 98.1% after 1, 2, and 3 rounds of MDA. Rates of filarial antigenemia assessed by card test (a marker for adult worm infection) decreased from 47.5% to 17.1% (a 64% decrease) after 3 rounds of MDA. The filarial antibody rate (IgG(4) antibodies to Bm14, an indicator of filarial infection status and/or exposure to mosquito-borne infective larvae) decreased from 59.3% to 25.1% (a 54.6% decrease). Mf, antigen, and antibody rates decreased more rapidly in children |
| doi_str_mv | 10.1371/journal.pntd.0000344 |
| format | article |
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Residents of rural villages near Madang were studied prior to and one year after each of three rounds of MDA with diethylcarbamazine plus albendazole administered per World Health Organization (WHO) guidelines. The mean MDA compliance rate was 72.9%. Three rounds of MDA decreased microfilaremia rates (Mf, 1 ml night blood by filter) from 18.6% pre-MDA to 1.3% after the third MDA (a 94% decrease). Mf clearance rates in infected persons were 71%, 90.7%, and 98.1% after 1, 2, and 3 rounds of MDA. Rates of filarial antigenemia assessed by card test (a marker for adult worm infection) decreased from 47.5% to 17.1% (a 64% decrease) after 3 rounds of MDA. The filarial antibody rate (IgG(4) antibodies to Bm14, an indicator of filarial infection status and/or exposure to mosquito-borne infective larvae) decreased from 59.3% to 25.1% (a 54.6% decrease). Mf, antigen, and antibody rates decreased more rapidly in children <11 years of age (by 100%, 84.2%, and 76.8%, respectively) relative to older individuals, perhaps reflecting their lighter infections and shorter durations of exposure/infection prior to MDA. Incidence rates for microfilaremia, filarial antigenemia, and antifilarial antibodies also decreased significantly after MDA. Filarial DNA rates in Anopheles punctulatus mosquitoes that had recently taken a blood meal decreased from 15.1% to 1.0% (a 92.3% decrease).
MDA had dramatic effects on all filariasis parameters in the study area and also reduced incidence rates. Follow-up studies will be needed to determine whether residual infection rates in residents of these villages are sufficient to support sustained transmission by the An. punctulatus vector. Lymphatic filariasis elimination should be feasible in Papua New Guinea if MDA can be effectively delivered to endemic populations.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0000344</identifier><identifier>PMID: 19065257</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aging ; Albendazole - administration & dosage ; Albendazole - therapeutic use ; Animals ; Anopheles - parasitology ; Anopheles punctulatus ; Anthelmintics - administration & dosage ; Anthelmintics - therapeutic use ; Antibodies ; Antigens ; Antigens, Helminth - blood ; Child ; Culicidae - parasitology ; Diethylcarbamazine - administration & dosage ; Diethylcarbamazine - therapeutic use ; DNA, Helminth - genetics ; Drug dosages ; Drug Therapy, Combination ; Elephantiasis, Filarial - epidemiology ; Elephantiasis, Filarial - immunology ; Elephantiasis, Filarial - prevention & control ; Filariasis - blood ; Filariasis - epidemiology ; Filariasis - immunology ; Humans ; Infections ; Infectious diseases ; Infectious Diseases/Epidemiology and Control of Infectious Diseases ; Infectious Diseases/Helminth Infections ; Infectious Diseases/Neglected Tropical Diseases ; Malaria ; Mosquitoes ; Papua New Guinea - epidemiology ; Parasites ; Patient Compliance ; Prevalence ; Public health ; Tropical diseases</subject><ispartof>PLoS neglected tropical diseases, 2008-12, Vol.2 (12), p.e344-e344</ispartof><rights>2008 Weil et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Weil GJ, Kastens W, Susapu M, Laney SJ, Williams SA, et al. (2008) The Impact of Repeated Rounds of Mass Drug Administration with Diethylcarbamazine Plus Albendazole on Bancroftian Filariasis in Papua New Guinea. PLoS Negl Trop Dis 2(12): e344. doi:10.1371/journal.pntd.0000344</rights><rights>Weil et al. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-40b1aafc6ee85c0d5618146c534d52af87ccca78d852a79febeeec15a0434f7e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1288102983/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1288102983?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19065257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lammie, Patrick J.</contributor><creatorcontrib>Weil, Gary J</creatorcontrib><creatorcontrib>Kastens, Will</creatorcontrib><creatorcontrib>Susapu, Melinda</creatorcontrib><creatorcontrib>Laney, Sandra J</creatorcontrib><creatorcontrib>Williams, Steven A</creatorcontrib><creatorcontrib>King, Christopher L</creatorcontrib><creatorcontrib>Kazura, James W</creatorcontrib><creatorcontrib>Bockarie, Moses J</creatorcontrib><title>The impact of repeated rounds of mass drug administration with diethylcarbamazine plus albendazole on bancroftian filariasis in Papua New Guinea</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>This study employed various monitoring methods to assess the impact of repeated rounds of mass drug administration (MDA) on bancroftian filariasis in Papua New Guinea, which has the largest filariasis problem in the Pacific region.
Residents of rural villages near Madang were studied prior to and one year after each of three rounds of MDA with diethylcarbamazine plus albendazole administered per World Health Organization (WHO) guidelines. The mean MDA compliance rate was 72.9%. Three rounds of MDA decreased microfilaremia rates (Mf, 1 ml night blood by filter) from 18.6% pre-MDA to 1.3% after the third MDA (a 94% decrease). Mf clearance rates in infected persons were 71%, 90.7%, and 98.1% after 1, 2, and 3 rounds of MDA. Rates of filarial antigenemia assessed by card test (a marker for adult worm infection) decreased from 47.5% to 17.1% (a 64% decrease) after 3 rounds of MDA. The filarial antibody rate (IgG(4) antibodies to Bm14, an indicator of filarial infection status and/or exposure to mosquito-borne infective larvae) decreased from 59.3% to 25.1% (a 54.6% decrease). Mf, antigen, and antibody rates decreased more rapidly in children <11 years of age (by 100%, 84.2%, and 76.8%, respectively) relative to older individuals, perhaps reflecting their lighter infections and shorter durations of exposure/infection prior to MDA. Incidence rates for microfilaremia, filarial antigenemia, and antifilarial antibodies also decreased significantly after MDA. Filarial DNA rates in Anopheles punctulatus mosquitoes that had recently taken a blood meal decreased from 15.1% to 1.0% (a 92.3% decrease).
MDA had dramatic effects on all filariasis parameters in the study area and also reduced incidence rates. Follow-up studies will be needed to determine whether residual infection rates in residents of these villages are sufficient to support sustained transmission by the An. punctulatus vector. Lymphatic filariasis elimination should be feasible in Papua New Guinea if MDA can be effectively delivered to endemic populations.</description><subject>Adult</subject><subject>Aging</subject><subject>Albendazole - administration & dosage</subject><subject>Albendazole - therapeutic use</subject><subject>Animals</subject><subject>Anopheles - parasitology</subject><subject>Anopheles punctulatus</subject><subject>Anthelmintics - administration & dosage</subject><subject>Anthelmintics - therapeutic use</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Antigens, Helminth - blood</subject><subject>Child</subject><subject>Culicidae - parasitology</subject><subject>Diethylcarbamazine - administration & dosage</subject><subject>Diethylcarbamazine - therapeutic use</subject><subject>DNA, Helminth - genetics</subject><subject>Drug dosages</subject><subject>Drug Therapy, Combination</subject><subject>Elephantiasis, Filarial - epidemiology</subject><subject>Elephantiasis, Filarial - immunology</subject><subject>Elephantiasis, Filarial - prevention & control</subject><subject>Filariasis - blood</subject><subject>Filariasis - epidemiology</subject><subject>Filariasis - immunology</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Infectious Diseases/Epidemiology and Control of Infectious Diseases</subject><subject>Infectious Diseases/Helminth Infections</subject><subject>Infectious Diseases/Neglected Tropical Diseases</subject><subject>Malaria</subject><subject>Mosquitoes</subject><subject>Papua New Guinea - epidemiology</subject><subject>Parasites</subject><subject>Patient Compliance</subject><subject>Prevalence</subject><subject>Public health</subject><subject>Tropical diseases</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9ksFu1DAQhiMEoqXwBggsIcFpFzuOE-eChCoolSrgUM7WxJ7seuXYwU6o2qfgkfGyAVqE8MX2-Jvf9sxfFE8ZXTPesNe7MEcPbj36yaxpHryq7hXHrOViVTZc3L-1PioepbSjVLRCsofFEWtpLUrRHBffL7dI7DCCnkjoScQRYUJDYpi9SfvQACkRE-cNATNYb9MUYbLBkys7bYmxOG2vnYbYwQA31iMZ3ZwIuA69gZvgkGS2A69j6CcLnvTWQbSQbCLWk88wzkA-4hU5m3M2PC4e9OASPlnmk-LL-3eXpx9WF5_Ozk_fXqy0EPW0qmjHAHpdI0qhqRE1k6yqteCVESX0stFaQyONzLum7bFDRM0E0IpXfYP8pHh-0B1dSGopZlKslJLRspU8E-cHwgTYqTHaAeK1CmDVz0CIGwVxstqhEroWfYdVyxqstGw6VnOBDaOyrErDu6z1Zrlt7gY0Gn2uorsjevfE263ahG-qFLLOrcoCrxaBGL7OmCY12KTROfAY5qQazmVTl6LO5Mv_kiXlNPtHZvDFX-C_q1AdqNy_lCL2vx_NqNob8VeW2htRLUbMac9uf_hP0uI8_gOGet-P</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Weil, Gary J</creator><creator>Kastens, Will</creator><creator>Susapu, Melinda</creator><creator>Laney, Sandra J</creator><creator>Williams, Steven A</creator><creator>King, Christopher L</creator><creator>Kazura, James W</creator><creator>Bockarie, Moses J</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T2</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QO</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20081201</creationdate><title>The impact of repeated rounds of mass drug administration with diethylcarbamazine plus albendazole on bancroftian filariasis in Papua New Guinea</title><author>Weil, Gary J ; Kastens, Will ; Susapu, Melinda ; Laney, Sandra J ; Williams, Steven A ; King, Christopher L ; Kazura, James W ; Bockarie, Moses J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-40b1aafc6ee85c0d5618146c534d52af87ccca78d852a79febeeec15a0434f7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aging</topic><topic>Albendazole - administration & dosage</topic><topic>Albendazole - therapeutic use</topic><topic>Animals</topic><topic>Anopheles - parasitology</topic><topic>Anopheles punctulatus</topic><topic>Anthelmintics - administration & dosage</topic><topic>Anthelmintics - therapeutic use</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Antigens, Helminth - blood</topic><topic>Child</topic><topic>Culicidae - parasitology</topic><topic>Diethylcarbamazine - administration & dosage</topic><topic>Diethylcarbamazine - therapeutic use</topic><topic>DNA, Helminth - genetics</topic><topic>Drug dosages</topic><topic>Drug Therapy, Combination</topic><topic>Elephantiasis, Filarial - epidemiology</topic><topic>Elephantiasis, Filarial - immunology</topic><topic>Elephantiasis, Filarial - prevention & control</topic><topic>Filariasis - blood</topic><topic>Filariasis - epidemiology</topic><topic>Filariasis - immunology</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Infectious Diseases/Epidemiology and Control of Infectious Diseases</topic><topic>Infectious Diseases/Helminth Infections</topic><topic>Infectious Diseases/Neglected Tropical Diseases</topic><topic>Malaria</topic><topic>Mosquitoes</topic><topic>Papua New Guinea - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weil, Gary J</au><au>Kastens, Will</au><au>Susapu, Melinda</au><au>Laney, Sandra J</au><au>Williams, Steven A</au><au>King, Christopher L</au><au>Kazura, James W</au><au>Bockarie, Moses J</au><au>Lammie, Patrick J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of repeated rounds of mass drug administration with diethylcarbamazine plus albendazole on bancroftian filariasis in Papua New Guinea</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>2</volume><issue>12</issue><spage>e344</spage><epage>e344</epage><pages>e344-e344</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>This study employed various monitoring methods to assess the impact of repeated rounds of mass drug administration (MDA) on bancroftian filariasis in Papua New Guinea, which has the largest filariasis problem in the Pacific region.
Residents of rural villages near Madang were studied prior to and one year after each of three rounds of MDA with diethylcarbamazine plus albendazole administered per World Health Organization (WHO) guidelines. The mean MDA compliance rate was 72.9%. Three rounds of MDA decreased microfilaremia rates (Mf, 1 ml night blood by filter) from 18.6% pre-MDA to 1.3% after the third MDA (a 94% decrease). Mf clearance rates in infected persons were 71%, 90.7%, and 98.1% after 1, 2, and 3 rounds of MDA. Rates of filarial antigenemia assessed by card test (a marker for adult worm infection) decreased from 47.5% to 17.1% (a 64% decrease) after 3 rounds of MDA. The filarial antibody rate (IgG(4) antibodies to Bm14, an indicator of filarial infection status and/or exposure to mosquito-borne infective larvae) decreased from 59.3% to 25.1% (a 54.6% decrease). Mf, antigen, and antibody rates decreased more rapidly in children <11 years of age (by 100%, 84.2%, and 76.8%, respectively) relative to older individuals, perhaps reflecting their lighter infections and shorter durations of exposure/infection prior to MDA. Incidence rates for microfilaremia, filarial antigenemia, and antifilarial antibodies also decreased significantly after MDA. Filarial DNA rates in Anopheles punctulatus mosquitoes that had recently taken a blood meal decreased from 15.1% to 1.0% (a 92.3% decrease).
MDA had dramatic effects on all filariasis parameters in the study area and also reduced incidence rates. Follow-up studies will be needed to determine whether residual infection rates in residents of these villages are sufficient to support sustained transmission by the An. punctulatus vector. Lymphatic filariasis elimination should be feasible in Papua New Guinea if MDA can be effectively delivered to endemic populations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19065257</pmid><doi>10.1371/journal.pntd.0000344</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2008-12, Vol.2 (12), p.e344-e344 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_1288102983 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Adult Aging Albendazole - administration & dosage Albendazole - therapeutic use Animals Anopheles - parasitology Anopheles punctulatus Anthelmintics - administration & dosage Anthelmintics - therapeutic use Antibodies Antigens Antigens, Helminth - blood Child Culicidae - parasitology Diethylcarbamazine - administration & dosage Diethylcarbamazine - therapeutic use DNA, Helminth - genetics Drug dosages Drug Therapy, Combination Elephantiasis, Filarial - epidemiology Elephantiasis, Filarial - immunology Elephantiasis, Filarial - prevention & control Filariasis - blood Filariasis - epidemiology Filariasis - immunology Humans Infections Infectious diseases Infectious Diseases/Epidemiology and Control of Infectious Diseases Infectious Diseases/Helminth Infections Infectious Diseases/Neglected Tropical Diseases Malaria Mosquitoes Papua New Guinea - epidemiology Parasites Patient Compliance Prevalence Public health Tropical diseases |
| title | The impact of repeated rounds of mass drug administration with diethylcarbamazine plus albendazole on bancroftian filariasis in Papua New Guinea |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T07%3A56%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20impact%20of%20repeated%20rounds%20of%20mass%20drug%20administration%20with%20diethylcarbamazine%20plus%20albendazole%20on%20bancroftian%20filariasis%20in%20Papua%20New%20Guinea&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Weil,%20Gary%20J&rft.date=2008-12-01&rft.volume=2&rft.issue=12&rft.spage=e344&rft.epage=e344&rft.pages=e344-e344&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0000344&rft_dat=%3Cproquest_plos_%3E2893305991%3C/proquest_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c556t-40b1aafc6ee85c0d5618146c534d52af87ccca78d852a79febeeec15a0434f7e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1288102983&rft_id=info:pmid/19065257&rfr_iscdi=true |