Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease

Konzo is a distinct neurological entity with selective upper motor neuron damage, characterized by an abrupt onset of an irreversible, non-progressive, and symmetrical spastic para/tetraparesis. Despite its severity, konzo remains a neglected disease. The disease is associated with high dietary cyan...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2011-06, Vol.5 (6), p.e1051
Main Authors: Nzwalo, Hipólito, Cliff, Julie
Format: Article
Language:English
Subjects:
Africa - epidemiology
Amino acids
Cassava
Cyanogen (Compound)
Disease
Drought
Epidemics
Food
Health aspects
Humans
Manihot - toxicity
Methods
Mortality
Neglected Diseases - chemically induced
Neglected Diseases - epidemiology
Nervous System Diseases - chemically induced
Nervous System Diseases - epidemiology
Neurological Disorders
Nitriles - toxicity
Poverty
Proteins
Review
Rural areas
Tropical diseases
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Description
Summary:Konzo is a distinct neurological entity with selective upper motor neuron damage, characterized by an abrupt onset of an irreversible, non-progressive, and symmetrical spastic para/tetraparesis. Despite its severity, konzo remains a neglected disease. The disease is associated with high dietary cyanogen consumption from insufficiently processed roots of bitter cassava combined with a protein-deficient diet. Epidemics occur when these conditions coincide at times of severe food shortage. Up to 1993, outbreaks in poor rural areas in Africa contributed to more than 3,700 cases of konzo. The number of affected people is underestimated. From unofficial reports, the number of cases was estimated to be at least 100,000 in 2000, in contrast to the 6,788 cases reported up to 2009 from published papers.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0001051