Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin

Because of the development of resistance in trypanosomes to trypanocidal drugs, the livelihood of millions of livestock keepers in sub-Saharan Africa is threatened now more than ever. The existing compounds have become virtually useless and pharmaceutical companies are not keen on investing in the d...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2010-09, Vol.4 (9), p.e828-e828
Main Authors: Delespaux, Vincent, Vitouley, Hervé Sèna, Marcotty, Tanguy, Speybroeck, Niko, Berkvens, Dirk, Roy, Krisna, Geerts, Stanny, Van den Bossche, Peter
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Antiprotozoal Agents - administration & dosage
Antiprotozoal Agents - pharmacology
Cattle
Disease Models, Animal
Drug dosages
Drug resistance
Drug Resistance - drug effects
Drug Therapy, Combination - methods
Experiments
Fluoroquinolones - administration & dosage
Fluoroquinolones - pharmacology
Glossina
Infectious Diseases/Antimicrobials and Drug Resistance
Infectious Diseases/Protozoal Infections
Infectious Diseases/Tropical and Travel-Associated Diseases
Livestock
Mice
Parasitemia - drug therapy
Parasitemia - parasitology
Pharmaceutical industry
Phenanthridines - administration & dosage
Phenanthridines - pharmacology
Rural areas
Rural development
Survival Analysis
Tetracyclines - administration & dosage
Tetracyclines - pharmacology
Treatment Outcome
Tropical diseases
Trypanosoma
Trypanosoma congolense
Trypanosoma congolense - drug effects
Trypanosomiasis, African - drug therapy
Trypanosomiasis, African - parasitology
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Summary:Because of the development of resistance in trypanosomes to trypanocidal drugs, the livelihood of millions of livestock keepers in sub-Saharan Africa is threatened now more than ever. The existing compounds have become virtually useless and pharmaceutical companies are not keen on investing in the development of new trypanocides. We may have found a breakthrough in the treatment of resistant trypanosomal infections, through the combination of the trypanocide isometamidium chloride (ISM) with two affordable veterinary antibiotics. In a first experiment, groups of mice were inoculated with Trypanosoma congolense strains resistant to ISM and either left untreated or treated with (i) tetracycline, (ii) ISM or (iii) the combination of the antibiotic and the trypanocide. Survival analysis showed that there was a significant effect of treatment and resistance to treatment on the survival time. The groups treated with ISM (with or without antibiotic) survived significantly longer than the groups that were not treated with ISM (P
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0000828