Risk factors for death in children with visceral leishmaniasis

Despite the major public health importance of visceral leishmaniasis (VL) in Latin America, well-designed studies to inform diagnosis, treatment and control interventions are scarce. Few observational studies address prognostic assessment in patients with VL. This study aimed to identify risk factor...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2010-11, Vol.4 (11), p.e877-e877
Main Authors: Sampaio, Márcia Jaqueline Alves de Queiroz, Cavalcanti, Nara Vasconcelos, Alves, João Guilherme Bezerra, Filho, Mário Jorge Costa Fernandes, Correia, Jailson B
Format: Article
Language:English
Subjects:
Adolescent
Antibiotics
Bacterial diseases
Bacterial infections
Blood products
Brazil - epidemiology
Child
Child, Preschool
Epidemiology
Ethics
Fatalities
Female
Hospitals
Humans
Infant
Infections
Infectious Diseases/Neglected Tropical Diseases
Infectious Diseases/Protozoal Infections
Leishmania
Leishmaniasis, Visceral - epidemiology
Leishmaniasis, Visceral - mortality
Male
Medical prognosis
Mortality
Observational studies
Parasitic diseases
Pediatrics and Child Health
Public health
Public Health and Epidemiology/Infectious Diseases
Retrospective Studies
Risk Factors
Sociodemographics
Tropical diseases
Vector-borne diseases
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Summary:Despite the major public health importance of visceral leishmaniasis (VL) in Latin America, well-designed studies to inform diagnosis, treatment and control interventions are scarce. Few observational studies address prognostic assessment in patients with VL. This study aimed to identify risk factors for death in children aged less than 15 years admitted for VL treatment in a referral center in northeast Brazil. In a retrospective cohort, we reviewed 546 records of patients younger than 15 years admitted with the diagnosis of VL at the Instituto de Medicina Integral Professor Fernando Figueira between May 1996 and June 2006. Age ranged from 4 months to 13.7 years, and 275 (50%) were male. There were 57 deaths, with a case-fatality rate of 10%. In multivariate logistic regression, the independent predictors of risk of dying from VL were (adjusted OR, 95% CI): mucosal bleeding (4.1, 1.3-13.4), jaundice (4.4, 1.7-11.2), dyspnea (2.8, 1.2-6.1), suspected or confirmed bacterial infections (2.7, 1.2-6.1), neutrophil count
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0000877