Midgut barrier imparts selective resistance to filarial worm infection in Culex pipiens pipiens

Mosquitoes in the Culex pipiens complex thrive in temperate and tropical regions worldwide, and serve as efficient vectors of Bancroftian lymphatic filariasis (LF) caused by Wuchereria bancrofti in Asia, Africa, the West Indies, South America, and Micronesia. However, members of this mosquito comple...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2010-11, Vol.4 (11), p.e875-e875
Main Authors: Michalski, Michelle L, Erickson, Sara M, Bartholomay, Lyric C, Christensen, Bruce M
Format: Article
Language:English
Subjects:
Aedes - parasitology
Animals
Arthropoda
Brugia
Brugia - isolation & purification
Brugia - physiology
Brugia malayi
Culex - parasitology
Culex pipiens
Culex pipiens pipiens
Digestive System - parasitology
Female
Filariasis - parasitology
Gerbillinae
Host-Parasite Interactions
Humans
Hypodermis
Infections
Infectious Diseases/Helminth Infections
Infectious Diseases/Neglected Tropical Diseases
Initiatives
Insect Vectors - parasitology
Mosquitoes
Motility
Nematoda
Parasites
Public Health and Epidemiology/Infectious Diseases
Tropical diseases
Urban areas
Wuchereria
Wuchereria bancrofti
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Summary:Mosquitoes in the Culex pipiens complex thrive in temperate and tropical regions worldwide, and serve as efficient vectors of Bancroftian lymphatic filariasis (LF) caused by Wuchereria bancrofti in Asia, Africa, the West Indies, South America, and Micronesia. However, members of this mosquito complex do not act as natural vectors for Brugian LF caused by Brugia malayi, or for the cat parasite B. pahangi, despite their presence in South Asia where these parasites are endemic. Previous work with the Iowa strain of Culex pipiens pipiens demonstrates that it is equally susceptible to W. bancrofti as is the natural Cx. p. pipiens vector in the Nile Delta, however it is refractory to infection with Brugia spp. Here we report that the infectivity barrier for Brugia spp. in Cx. p. pipiens is the mosquito midgut, which inflicts internal and lethal damage to ingested microfilariae. Following per os Brugia exposures, the prevalence of infection is significantly lower in Cx. p. pipiens compared to susceptible mosquito controls, and differs between parasite species with
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0000875