HIV-1 group M conserved elements vaccine

Many studies underscored the challenge of broadening CTL recognition through vaccination as they reflected typical HIV immunodominance profiles: the immune system focuses on relatively few immunodominant epitopes, leaving many epitopes subdominant or cryptic. Since subdominant responses may be criti...

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Bibliographic Details
Published in:PLoS pathogens 2007-11, Vol.3 (11), p.e157-e157
Main Authors: Rolland, Morgane, Nickle, David C, Mullins, James I
Format: Article
Language:English
Subjects:
AIDS Vaccines - genetics
Amino Acid Sequence
Animals
Base Sequence
Conserved Sequence
Cytotoxicity
Design
HIV
HIV-1 - genetics
Homo (Human)
Human immunodeficiency virus
Humans
Immune system
Immunogenicity
Immunology
Immunotherapy, Active - methods
Infections
Lymphocytes
Multiculturalism & pluralism
Mutation
Opinions
Peptides
Proteins
Vaccines
Viral Proteins - genetics
Virology
Viruses
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Summary:Many studies underscored the challenge of broadening CTL recognition through vaccination as they reflected typical HIV immunodominance profiles: the immune system focuses on relatively few immunodominant epitopes, leaving many epitopes subdominant or cryptic. Since subdominant responses may be critical to effective suppression [37], mitigating immunodominance patterns could prove critical for successful vaccines.\n Additional epitopes were found to overlap CE/non-CE junctions (data not shown); thus extending CE immunogens could increase the number of peptides available to CD8+ T lymphocytes. [...]CE constructs have to be engineered optimally to elicit immune responses by capitalizing on the mechanisms governing epitope processing and presentation while preventing the creation of junctional immunogenicity or homology to the HIV or human proteome [52].
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.0030157