Endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept

Idiopathic pulmonary fibrosis (IPF) has been associated with abnormal vascular remodeling. Bone marrow derived endothelial progenitor cells (EPCs) are considered to possess lung tissue repair and vascular remodeling properties. The study aimed to assess early EPCs levels and EPCs endogenous vascular...

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Bibliographic Details
Published in:PloS one 2013-01, Vol.8 (1), p.e53658-e53658
Main Authors: Malli, Foteini, Koutsokera, Angela, Paraskeva, Efrosini, Zakynthinos, Epaminondas, Papagianni, Maria, Makris, Dimosthenes, Tsilioni, Irene, Molyvdas, Paschalis Adam, Gourgoulianis, Konstantinos I, Daniil, Zoe
Format: Article
Language:English
Subjects:
Aged
Biology
Blood pressure
Bone marrow
Bone Marrow Cells - pathology
Bone remodeling
Cell Culture Techniques
Cells (biology)
Colonies
Critical care
Endothelial Cells - pathology
Endothelium
Family medical history
Fibrosis
Gene Expression Regulation
Hospitals
Humans
Hypoxia
Idiopathic Pulmonary Fibrosis - etiology
Idiopathic Pulmonary Fibrosis - metabolism
Idiopathic Pulmonary Fibrosis - pathology
Idiopathic Pulmonary Fibrosis - physiopathology
Lung diseases
Male
Medicine
mRNA
Neovascularization, Pathologic
Osteoprogenitor cells
Pathogenesis
Patients
Physiology
Plasma levels
Pulmonary fibrosis
Pulmonary hypertension
Repair
Respiratory tract diseases
RNA
RNA, Messenger - genetics
RNA, Messenger - metabolism
Solubility
Stem cells
Stem Cells - pathology
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - blood
Vascular Endothelial Growth Factor A - chemistry
Vascular Endothelial Growth Factor A - genetics
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Summary:Idiopathic pulmonary fibrosis (IPF) has been associated with abnormal vascular remodeling. Bone marrow derived endothelial progenitor cells (EPCs) are considered to possess lung tissue repair and vascular remodeling properties. The study aimed to assess early EPCs levels and EPCs endogenous vascular endothelial growth factor (VEGF) expression in IPF. In order to examine alterations in the mobilization of EPCs from the bone marrow we measured plasma VEGF. Twenty-three patients with IPF and fifteen healthy subjects were included. The number of early EPCs colonies was markedly reduced in IPF patients vs controls (6.00±6.49 vs 49.68±16.73, respectively, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0053658